Stau2 - staufen double-stranded RNA binding protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171500

Summary

Enables several functions, including HSP70 protein binding activity; Kinesin binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Part of messenger ribonucleoprotein complex. Used to study microphthalmia. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Stau2 Products (4)

mRNA	Protein	Name
NM_001007149.2	NP_001007150.2	double-stranded RNA-binding protein Staufen homolog 2 isoform LL (A)
NM_001007150.2	NP_001007151.1	double-stranded RNA-binding protein Staufen homolog 2 isoform SS
NM_001393676.1	NP_001380605.1	double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)
NM_134466.4	NP_604461.2	double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	20596529	RGD
enables kinesin binding	IDA IDA: Inferred from direct assay	17587311	RGD
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	18492489	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15970630	RGD
enables ribosome binding	IDA IDA: Inferred from direct assay	12140260	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in anterograde dendritic transport of messenger ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16418534	RGD
involved in anterograde dendritic transport of messenger ribonucleoprotein complex	IEP IEP: Inferred from expression pattern	16418534	RGD
involved in anterograde dendritic transport of messenger ribonucleoprotein complex	IMP IMP: Inferred from mutant phenotype	16418534	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	15525674	RGD
involved in eye morphogenesis	IMP IMP: Inferred from mutant phenotype	22940085	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	16418534	RGD
involved in positive regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	21508097	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	16418534	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16418534	RGD
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	16418534	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	16809002	RGD
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	15525674	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12140260	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	16418534	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16418534	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12140260	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	15970630	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	16418534	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20596529	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
double-stranded RNA-binding protein Staufen homolog 2	r-staufen protein staufen, RNA binding protein, homolog 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13901	STAU2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stau2	NCBI	NCBI:27067