STAU2 - staufen double-stranded RNA binding protein 2 Gene

Also Known as 39K2; 39K3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 27067

About STAU2

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,420,369-73,747,480 (from NCBI)

This gene has 29 transcripts (splice variants), 199 orthologues and 14 paralogues. Ubiquitous expression in brain (RPKM 12.9), heart (RPKM 8.7) and 25 other tissues.

Summary

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

STAU2 Products (7)

mRNA Protein Name
NM_001164380.2 NP_001157852.1 double-stranded RNA-binding protein Staufen homolog 2 isoform a
NM_001164381.2 NP_001157853.1 double-stranded RNA-binding protein Staufen homolog 2 isoform b
NM_001164382.2 NP_001157854.1 double-stranded RNA-binding protein Staufen homolog 2 isoform c
NM_001164383.2 NP_001157855.1 double-stranded RNA-binding protein Staufen homolog 2 isoform d
NM_001164384.2 NP_001157856.1 double-stranded RNA-binding protein Staufen homolog 2 isoform e
NM_001164385.2 NP_001157857.1 double-stranded RNA-binding protein Staufen homolog 2 isoform f
NM_014393.3 NP_055208.2 double-stranded RNA-binding protein Staufen homolog 2 isoform e

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21266579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAU2 Protein Structure

dsrm

dsrm: Double-stranded RNA binding motif (10 - 70)

dsrm

dsrm: Double-stranded RNA binding motif (144 - 179)

dsrm

dsrm: Double-stranded RNA binding motif (209 - 272)

dsrm

dsrm: Double-stranded RNA binding motif (308 - 373)

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  • 570 a.a.
Protein Preferred Names Protein Names

double-stranded RNA-binding protein Staufen homolog 2

  • staufen homolog 2

STAU2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Cross
STAU2 Q9NUL3 P0DTD1-PRO_0000449620 SARS-CoV-2 P0DTD1-PRO_0000449620
BLI
34159380
Intra
STAU2 Q9NUL3 DHX58 Homo sapiens Q96C10
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13901 STAU2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus STAU2 VGNC VGNC:65765
Mus musculus STAU2 MGD MGI:1352508
Bos taurus STAU2 VGNC VGNC:106955
Macaca mulatta STAU2 VGNC VGNC:84119
Canis familiaris STAU2 VGNC VGNC:46894
Rattus norvegicus STAU2 RGD RGD:621479
Others STAU2 NCBI