Man2a1 - mannosidase 2, alpha 1 Gene

Also Known as Mana2; Map-2; Mana-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17158

Summary

Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Acts upstream of or within several processes, including N-glycan processing; animal organ development; and positive regulation of neurogenesis. Located in Golgi membrane; cis-Golgi network; and extracellular space. Is expressed in adrenal gland; gland; and white fat. Used to study congenital dyserythropoietic anemia and systemic lupus erythematosus. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Man2a1 Products (1)

mRNA Protein Name
NM_008549.2 NP_032575.2 alpha-mannosidase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hydrolase activity IDA
IDA: Inferred from direct assay
19710420 MGI
enables hydrolase activity, hydrolyzing N-glycosyl compounds IDA
IDA: Inferred from direct assay
16754854 MGI
enables mannosidase activity IDA
IDA: Inferred from direct assay
16754854 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within N-glycan processing IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within lung alveolus development IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within mitochondrion organization IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20144606 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IGI
IGI: Inferred from genetic interaction
16754854 MGI
acts upstream of or within retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
20144606 MGI
acts upstream of or within vacuole organization IGI
IGI: Inferred from genetic interaction
16754854 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16204232 MGI
located in Golgi membrane IDA
IDA: Inferred from direct assay
11042173 MGI
located in cis-Golgi network IDA
IDA: Inferred from direct assay
22841714 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
19710420 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-mannosidase 2

  • AMan II

  • golgi alpha-mannosidase II

  • man II

  • mannosidase alpha class 2A member 1

  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D3187 HMRef-αMan Substrate / Unkown
HY-RS08008 MAN2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08010 MAN2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08012 MAN2C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Man2a1 NCBI NCBI:4124