Myo5a - myosin VA Gene

Also Known as d; Dbv; MVa; flr; Myo5; MyoVA; Sev-1; flail; d-120J; 9630007J19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17918

Summary

Enables several functions, including Calmodulin binding activity; disordered domain specific binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to Insulin stimulus; establishment of endoplasmic reticulum localization to postsynapse; and regulation of postsynaptic cytosolic calcium ion concentration. Acts upstream of or within several processes, including melanosome transport; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and secretion by cell. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and photoreceptor outer segment. Part of unconventional Myosin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in nervous system and retina. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (Myosin VA). [provided by Alliance of Genome Resources, Apr 2022]

Myo5a Products (1)

mRNA Protein Name
NM_010864.2 NP_034994.2 unconventional myosin-Va

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
11706052 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
15007063 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
11706052 MGI
enables cytoskeletal motor activity IDA
IDA: Inferred from direct assay
11706052 MGI
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
17513864 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20018767 MGI
enables microfilament motor activity IDA
IDA: Inferred from direct assay
11706052 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11266470 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
22908308 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament-based movement IDA
IDA: Inferred from direct assay
15007063 MGI
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
15550542 MGI
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
22908308 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
15316067 MGI
acts upstream of or within developmental pigmentation IMP
IMP: Inferred from mutant phenotype
15550542 MGI
acts upstream of or within endoplasmic reticulum localization IMP
IMP: Inferred from mutant phenotype
8899740 MGI
involved in establishment of endoplasmic reticulum localization to postsynapse IDA
IDA: Inferred from direct assay
21151132 MGI
involved in establishment of endoplasmic reticulum localization to postsynapse IMP
IMP: Inferred from mutant phenotype
21151132 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
15788565 MGI
acts upstream of or within hair follicle maturation IMP
IMP: Inferred from mutant phenotype
25340873 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
15788565 MGI
acts upstream of or within locomotion involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
10536275 MGI
acts upstream of or within long-chain fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
1150661 MGI
acts upstream of or within melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
7665913 MGI
acts upstream of or within melanin metabolic process IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
1996138 MGI
acts upstream of or within melanosome localization IMP
IMP: Inferred from mutant phenotype
8962090 MGI
acts upstream of or within melanosome transport IDA
IDA: Inferred from direct assay
9133672 MGI
acts upstream of or within melanosome transport IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
1150661 MGI
acts upstream of or within odontogenesis IDA
IDA: Inferred from direct assay
14730011 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22908308 MGI
acts upstream of or within regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
11086997 MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
21151132 MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
21151132 MGI
acts upstream of or within secretory granule localization IMP
IMP: Inferred from mutant phenotype
15788565 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
15316067 MGI
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
22908308 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
15316067 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
14724135 MGI
located in actomyosin IDA
IDA: Inferred from direct assay
8188282 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8962090 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21151132 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21151132 MGI
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
22908308 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
8188282 MGI
located in melanosome IDA
IDA: Inferred from direct assay
9133672 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
11706052 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
1996138 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
14978221 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
21151132 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
21151132 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
15788565 MGI
is active in smooth endoplasmic reticulum IDA
IDA: Inferred from direct assay
21151132 MGI
is active in smooth endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
21151132 MGI
part of unconventional myosin complex IMP
IMP: Inferred from mutant phenotype
17513864 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-Va

  • dilute lethal-20J protein

  • dilute myosin heavy chain, non-muscle

  • flailer

  • myosin-Va

Myo5a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Myo5a Q99104 Nos1 Mus musculus Q9Z0J4
Confocal
21680773
Intra
Myo5a Q99104 Slc17a9 Mus musculus Q8VCL5
PLA
22207579
Intra
Myo5a Q99104 Myo5a Mus musculus Q99104
TEM
20018767
Intra
Myo5a Q99104 Myo5a Mus musculus Q99104
TEM
20133809
Intra
Myo5a Q99104 Slc17a9 Mus musculus Q8VCL5
Confocal
22207579
Intra
Myo5a Q99104 ACTA1 Oryctolagus cuniculus P68135
TEM
20133809
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08946 MYO5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo5a NCBI NCBI:4644