Myo5a - myosin VA Gene

Mus musculus

Also known as d; Dbv; MVa; flr; Myo5; MyoVA; Sev-1; flail; d-120J; 9630007J19Rik

Gene ID: 17918 | Gene type: protein coding

About Myo5a

Summary

Enables several functions, including Calmodulin binding activity; disordered domain specific binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to Insulin stimulus; establishment of endoplasmic reticulum localization to postsynapse; and regulation of postsynaptic cytosolic calcium ion concentration. Acts upstream of or within several processes, including melanosome transport; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and secretion by cell. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and photoreceptor outer segment. Part of unconventional Myosin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in nervous system and retina. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (Myosin VA). [provided by Alliance of Genome Resources, Apr 2022]

Myo5a Products(1)

mRNA	Protein	Name
NM_010864.2	NP_034994.2	unconventional myosin-Va

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	11706052	MGI
enables calcium ion binding	IDA IDA: Inferred from direct assay	15007063	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	11706052	MGI
enables cytoskeletal motor activity	IDA IDA: Inferred from direct assay	11706052	MGI
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	17513864	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20018767	MGI
enables microfilament motor activity	IDA IDA: Inferred from direct assay	11706052	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11266470	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	22908308	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin filament-based movement	IDA IDA: Inferred from direct assay	15007063	MGI
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	15550542	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	22908308	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15316067	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	15550542	MGI
acts upstream of or within endoplasmic reticulum localization	IMP IMP: Inferred from mutant phenotype	8899740	MGI
involved in establishment of endoplasmic reticulum localization to postsynapse	IDA IDA: Inferred from direct assay	21151132	MGI
involved in establishment of endoplasmic reticulum localization to postsynapse	IMP IMP: Inferred from mutant phenotype	21151132	MGI
acts upstream of or within exocytosis	IMP IMP: Inferred from mutant phenotype	15788565	MGI
acts upstream of or within hair follicle maturation	IMP IMP: Inferred from mutant phenotype	25340873	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	15788565	MGI
acts upstream of or within locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	10536275	MGI
acts upstream of or within long-chain fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	1150661	MGI
acts upstream of or within melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	7665913	MGI
acts upstream of or within melanin metabolic process	IMP IMP: Inferred from mutant phenotype	9548375	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	1996138	MGI
acts upstream of or within melanosome localization	IMP IMP: Inferred from mutant phenotype	8962090	MGI
acts upstream of or within melanosome transport	IDA IDA: Inferred from direct assay	9133672	MGI
acts upstream of or within melanosome transport	IMP IMP: Inferred from mutant phenotype	9548375	MGI
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	1150661	MGI
acts upstream of or within odontogenesis	IDA IDA: Inferred from direct assay	14730011	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	2379821	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22908308	MGI
acts upstream of or within regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IMP IMP: Inferred from mutant phenotype	11086997	MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	21151132	MGI
involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	21151132	MGI
acts upstream of or within secretory granule localization	IMP IMP: Inferred from mutant phenotype	15788565	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	15316067	MGI
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	22908308	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	15316067	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	14724135	MGI
located in actomyosin	IDA IDA: Inferred from direct assay	8188282	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	8962090	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21151132	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21151132	MGI
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	22908308	MGI
located in intermediate filament	IDA IDA: Inferred from direct assay	8188282	MGI
located in melanosome	IDA IDA: Inferred from direct assay	9133672	MGI
part of myosin complex	IDA IDA: Inferred from direct assay	11706052	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	1996138	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	14978221	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	21151132	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	21151132	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	15788565	MGI
is active in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	21151132	MGI
is active in smooth endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	21151132	MGI
part of unconventional myosin complex	IMP IMP: Inferred from mutant phenotype	17513864	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-Va

dilute lethal-20J protein	dilute myosin heavy chain, non-muscle
flailer	myosin-Va

Myo5a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Myo5a	Q99104	Nos1	Mus musculus	Q9Z0J4	Confocal	21680773
Intra	Myo5a	Q99104	Slc17a9	Mus musculus	Q8VCL5	PLA	22207579
Intra	Myo5a	Q99104	Myo5a	Mus musculus	Q99104	TEM	20018767
Intra	Myo5a	Q99104	Myo5a	Mus musculus	Q99104	TEM	20133809
Intra	Myo5a	Q99104	Slc17a9	Mus musculus	Q8VCL5	Confocal	22207579
Intra	Myo5a	Q99104	ACTA1	Oryctolagus cuniculus	P68135	TEM	20133809

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08946	MYO5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo5a	NCBI	NCBI:4644

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