Ndufs4 - NADH:ubiquinone oxidoreductase core subunit S4 Gene

Mus musculus

Also known as C1-18k; 6720411N02Rik

Gene ID: 17993 | Gene type: protein coding

About Ndufs4

Summary

Enables NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within several processes, including adult walking behavior; mitochondrial respiratory chain complex I assembly; and psychomotor behavior. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Leigh disease and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs4 Products(1)

mRNA	Protein	Name
NM_010887.2	NP_035017.2	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADH dehydrogenase (ubiquinone) activity	IDA IDA: Inferred from direct assay	10747996	MGI
enables NADH dehydrogenase (ubiquinone) activity	IMP IMP: Inferred from mutant phenotype	18396137	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	28327638	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	26363424	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	28916769	MGI
acts upstream of or within cellular response to oxygen levels	IMP IMP: Inferred from mutant phenotype	26437605	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	28327638	MGI
acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	28327638	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	25652399	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	25652399	MGI
acts upstream of or within mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	18396137	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25652399	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	26363424	MGI
acts upstream of or within psychomotor behavior	IMP IMP: Inferred from mutant phenotype	28327638	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	29501746	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	26712463	MGI
acts upstream of or within respiratory electron transport chain	IMP IMP: Inferred from mutant phenotype	30391276	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	28327638	MGI
acts upstream of or within response to injury involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	29501746	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	18396137	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	25652399	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	18396137	MGI
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	10747996	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

CI-18 kDa	CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit	complex I-18 kDa
complex I-AQDQ

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172371	Hypoxystat		99.28%	Unkown
HY-121577	Sonlicromanol	Modulator	98.65%	Unkown
HY-RS09160	NDUFS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169281	Antiviral agent 61	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndufs4	NCBI	NCBI:4724

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