Ndufs4 - NADH:ubiquinone oxidoreductase core subunit S4 Gene

Also Known as C1-18k; 6720411N02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17993

Summary

Enables NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within several processes, including adult walking behavior; mitochondrial respiratory chain complex I assembly; and psychomotor behavior. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Leigh disease and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs4 Products (1)

mRNA Protein Name
NM_010887.2 NP_035017.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADH dehydrogenase (ubiquinone) activity IDA
IDA: Inferred from direct assay
10747996 MGI
enables NADH dehydrogenase (ubiquinone) activity IMP
IMP: Inferred from mutant phenotype
18396137 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
28327638 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
26363424 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
28916769 MGI
acts upstream of or within cellular response to oxygen levels IMP
IMP: Inferred from mutant phenotype
26437605 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
28327638 MGI
acts upstream of or within dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
28327638 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
25652399 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
25652399 MGI
acts upstream of or within mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
18396137 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
25652399 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
26363424 MGI
acts upstream of or within psychomotor behavior IMP
IMP: Inferred from mutant phenotype
28327638 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
29501746 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
26712463 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
30391276 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
28327638 MGI
acts upstream of or within response to injury involved in regulation of muscle adaptation IMP
IMP: Inferred from mutant phenotype
29501746 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
18396137 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
25652399 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
18396137 MGI
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
10747996 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

  • CI-18 kDa

  • CI-AQDQ

  • NADH-ubiquinone oxidoreductase 18 kDa subunit

  • complex I-18 kDa

  • complex I-AQDQ

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172371 Hypoxystat 99.28% Unkown
HY-121577 Sonlicromanol Modulator 98.65% Unkown
HY-RS09160 NDUFS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169281 Antiviral agent 61 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufs4 NCBI NCBI:4724