1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Sonlicromanol

Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease.

For research use only. We do not sell to patients.

Sonlicromanol Chemical Structure

Sonlicromanol Chemical Structure

CAS No. : 1541170-75-5

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Description

Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2].

In Vivo

Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ndufs4−/− mice[3].
Dosage: 10 mg/kg.
Administration: Twice daily by intraperitoneal injection.
Result: Increased lifespan of Ndufs4−/− mice similar as KH176 and Clofibrate single treatment.
Clinical Trial
Molecular Weight

332.44

Formula

C19H28N2O3

CAS No.
SMILES

CC1=C(C(C)=C2CC[C@@](C(N[C@@H]3CCCNC3)=O)(OC2=C1C)C)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Sonlicromanol
Cat. No.:
HY-121577
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