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  3. Sonlicromanol hydrochloride

Sonlicromanol hydrochloride (Synonyms: KH176 hydrochloride)

Cat. No.: HY-120332 Purity: 99.59%
Handling Instructions

Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders.

For research use only. We do not sell to patients.

Sonlicromanol hydrochloride Chemical Structure

Sonlicromanol hydrochloride Chemical Structure

CAS No. : 2162149-24-6

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3900 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sonlicromanol hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders[1].

In Vivo

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4−/− mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ndufs4−/− mice (Leigh Disease model)[1].
Dosage: 10 mg/kg.
Administration: IP, daily (PD14-PD45, 32 days).
Result: Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.
Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
Molecular Weight

368.90

Formula

C₁₉H₂₉ClN₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (460.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7108 mL 13.5538 mL 27.1076 mL
5 mM 0.5422 mL 2.7108 mL 5.4215 mL
10 mM 0.2711 mL 1.3554 mL 2.7108 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (13.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.25 mg/mL (11.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.25 mg/mL (11.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.59%

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Product Name:
Sonlicromanol hydrochloride
Cat. No.:
HY-120332
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