2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Sonlicromanol hydrochloride

Sonlicromanol hydrochloride  (Synonyms: KH176 hydrochloride)

Cat. No.: HY-120332 Purity: 99.85%
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Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders.

For research use only. We do not sell to patients.

Sonlicromanol hydrochloride Chemical Structure

Sonlicromanol hydrochloride Chemical Structure

CAS No. : 2162149-24-6

Size Price Stock Quantity
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 3900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sonlicromanol hydrochloride:

Sonlicromanol hydrochloride Related Antibodies

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Description

Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders[1].
In Vivo

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4−/− mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ndufs4−/− mice (Leigh Disease model)[1].
Dosage: 10 mg/kg.
Administration: IP, daily (PD14-PD45, 32 days).
Result: Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.
Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
Clinical Trial
Molecular Weight

368.90

Formula

C19H29ClN2O3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC1=C(C(C)=C2CC[C@@](C(N[C@@H]3CCCNC3)=O)(OC2=C1C)C)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (460.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (271.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7108 mL 13.5538 mL 27.1076 mL
5 mM 0.5422 mL 2.7108 mL 5.4215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (13.55 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

  • Protocol 2

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 4.25 mg/mL (11.52 mM); Clear solution

    This protocol yields a clear solution of ≥ 4.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (42.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.85%

COA (247 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.7108 mL 13.5538 mL 27.1076 mL 67.7690 mL
5 mM 0.5422 mL 2.7108 mL 5.4215 mL 13.5538 mL
10 mM 0.2711 mL 1.3554 mL 2.7108 mL 6.7769 mL
15 mM 0.1807 mL 0.9036 mL 1.8072 mL 4.5179 mL
20 mM 0.1355 mL 0.6777 mL 1.3554 mL 3.3885 mL
25 mM 0.1084 mL 0.5422 mL 1.0843 mL 2.7108 mL
30 mM 0.0904 mL 0.4518 mL 0.9036 mL 2.2590 mL
40 mM 0.0678 mL 0.3388 mL 0.6777 mL 1.6942 mL
50 mM 0.0542 mL 0.2711 mL 0.5422 mL 1.3554 mL
60 mM 0.0452 mL 0.2259 mL 0.4518 mL 1.1295 mL
80 mM 0.0339 mL 0.1694 mL 0.3388 mL 0.8471 mL
100 mM 0.0271 mL 0.1355 mL 0.2711 mL 0.6777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sonlicromanol2162149-24-6KH176KH 176KH-176Reactive Oxygen SpeciesOXPHOSLeighdiseaseganglionmtDNAInhibitorinhibitorinhibit

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