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Neurl1a - neuralized E3 ubiquitin protein ligase 1A Gene

Also Known as Nlz; Neu1; Neur1; Neurl; Rnf67; Neurl1; 2410129E16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18011

Summary

Enables translation factor activity, non-nucleic acid binding and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of long-term neuronal synaptic plasticity; and protein monoubiquitination. Acts upstream of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Neurl1a Products (2)

mRNA	Protein	Name
NM_001163480.1	NP_001156952.1	E3 ubiquitin-protein ligase NEURL1 isoform 2
NM_021360.4	NP_067335.4	E3 ubiquitin-protein ligase NEURL1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14960280	MGI
enables translation factor activity, non-nucleic acid binding	IDA IDA: Inferred from direct assay	22153079	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	22153079	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	22153079	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22153079	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	11585928	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	11585928	MGI
involved in positive regulation of dendritic spine development	IDA IDA: Inferred from direct assay	22153079	MGI
acts upstream of or within positive regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	11481456	MGI
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	22153079	MGI
involved in positive regulation of long-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	22153079	MGI
involved in positive regulation of synapse maturation	IDA IDA: Inferred from direct assay	22153079	MGI
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	22153079	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	22153079	MGI
involved in regulation of postsynapse assembly	IEP IEP: Inferred from expression pattern	22153079	MGI
acts upstream of or within sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	11585928	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	22153079	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11481456	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	22153079	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22153079	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	22153079	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	22153079	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11997106	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22153079	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	22153079	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	22153079	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase NEURL1	RING-type E3 ubiquitin transferase NEURL1 m-neu1 m-neuralized 1 neuralized homolog 1A neuralized-like homolog neuralized-like protein 1 neuralized-like protein 1A neuralized1

Neurl1a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Neurl1	Q923S6	Cpeb3	Mus musculus	Q7TN99	Anti Bait CoIP	22153079

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09219	NEURL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09220	NEURL1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown