Cpeb3 - cytoplasmic polyadenylation element binding protein 3 Gene

Mus musculus

Also known as CPE-BP3; mKIAA0940; 4831444O18Rik

Gene ID: 208922 | Gene type: protein coding

About Cpeb3

Summary

Enables nucleic acid binding activity. Involved in several processes, including long-term memory; positive regulation of long-term synaptic potentiation; and regulation of translation. Located in several cellular components, including apical dendrite; nucleus; and synapse. Is expressed in metanephros. Orthologous to human CPEB3 (cytoplasmic polyadenylation element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Cpeb3 Products(5)

mRNA	Protein	Name
NM_001290826.1	NP_001277755.1	cytoplasmic polyadenylation element-binding protein 3 isoform a
NM_001290827.1	NP_001277756.1	cytoplasmic polyadenylation element-binding protein 3 isoform a
NM_001290828.1	NP_001277757.1	cytoplasmic polyadenylation element-binding protein 3 isoform b
NM_001290829.1	NP_001277758.1	cytoplasmic polyadenylation element-binding protein 3 isoform c
NM_198300.3	NP_938042.2	cytoplasmic polyadenylation element-binding protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	17024188	MGI
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	17024188	MGI
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	17024188	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22153079	MGI
enables mRNA regulatory element binding translation repressor activity	IDA IDA: Inferred from direct assay	22157746	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22153079	MGI
enables translation factor activity, RNA binding	IDA IDA: Inferred from direct assay	22153079	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	17024188	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	24155305	MGI
involved in negative regulation of cytoplasmic translational elongation	IDA IDA: Inferred from direct assay	22157746	MGI
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	17024188	MGI
acts upstream of or within negative regulation of translation	IMP IMP: Inferred from mutant phenotype	17024188	MGI
involved in positive regulation of dendritic spine development	IDA IDA: Inferred from direct assay	22153079	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	26074003	MGI
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	22153079	MGI
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	26074003	MGI
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	24155305	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	22153079	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	22153079	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	24155305	MGI
involved in thermoception	IMP IMP: Inferred from mutant phenotype	26915043	MGI
acts upstream of translation	IMP IMP: Inferred from mutant phenotype	17024188	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	22153079	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20937770	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17024188	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22153079	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22153079	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22711986	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20937770	MGI
located in synapse	IDA IDA: Inferred from direct assay	17024188	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic polyadenylation element-binding protein 3

CPE-binding protein 3

Cpeb3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cpeb3	Q7TN99	Rps27a	Mus musculus	P62991	Anti Bait CoIP	22153079
Intra	Cpeb3	Q7TN99	Neurl1	Mus musculus	Q923S6	Anti Bait CoIP	22153079
Intra	Cpeb3	Q7TN99	Neurl1	Mus musculus	Q923S6	Confocal	22153079
Intra	Cpeb3	Q7TN99	Neurl1	Mus musculus	Q923S6	Anti Tag CoIP	22153079

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03093	CPEB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cpeb3	NCBI	NCBI:22849

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