Cpeb3 - cytoplasmic polyadenylation element binding protein 3 Gene

Also Known as CPE-BP3; mKIAA0940; 4831444O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208922

Summary

Enables nucleic acid binding activity. Involved in several processes, including long-term memory; positive regulation of long-term synaptic potentiation; and regulation of translation. Located in several cellular components, including apical dendrite; nucleus; and synapse. Is expressed in metanephros. Orthologous to human CPEB3 (cytoplasmic polyadenylation element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Cpeb3 Products (5)

mRNA Protein Name
NM_001290826.1 NP_001277755.1 cytoplasmic polyadenylation element-binding protein 3 isoform a
NM_001290827.1 NP_001277756.1 cytoplasmic polyadenylation element-binding protein 3 isoform a
NM_001290828.1 NP_001277757.1 cytoplasmic polyadenylation element-binding protein 3 isoform b
NM_001290829.1 NP_001277758.1 cytoplasmic polyadenylation element-binding protein 3 isoform c
NM_198300.3 NP_938042.2 cytoplasmic polyadenylation element-binding protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
17024188 MGI
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
17024188 MGI
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
17024188 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
22153079 MGI
enables mRNA regulatory element binding translation repressor activity IDA
IDA: Inferred from direct assay
22157746 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22153079 MGI
enables translation factor activity, RNA binding IDA
IDA: Inferred from direct assay
22153079 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
17024188 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
24155305 MGI
involved in negative regulation of cytoplasmic translational elongation IDA
IDA: Inferred from direct assay
22157746 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
17024188 MGI
acts upstream of or within negative regulation of translation IMP
IMP: Inferred from mutant phenotype
17024188 MGI
involved in positive regulation of dendritic spine development IDA
IDA: Inferred from direct assay
22153079 MGI
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
26074003 MGI
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
22153079 MGI
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
26074003 MGI
involved in regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
24155305 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
22153079 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
22153079 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
24155305 MGI
involved in thermoception IMP
IMP: Inferred from mutant phenotype
26915043 MGI
acts upstream of translation IMP
IMP: Inferred from mutant phenotype
17024188 MGI
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
22153079 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20937770 MGI
located in dendrite IDA
IDA: Inferred from direct assay
17024188 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22153079 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22153079 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
22711986 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20937770 MGI
located in synapse IDA
IDA: Inferred from direct assay
17024188 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic polyadenylation element-binding protein 3

  • CPE-binding protein 3

Cpeb3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cpeb3 Q7TN99 Rps27a Mus musculus P62991
Anti Bait CoIP
22153079
Intra
Cpeb3 Q7TN99 Neurl1 Mus musculus Q923S6
Anti Bait CoIP
22153079
Intra
Cpeb3 Q7TN99 Neurl1 Mus musculus Q923S6
Confocal
22153079
Intra
Cpeb3 Q7TN99 Neurl1 Mus musculus Q923S6
Anti Tag CoIP
22153079
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03093 CPEB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpeb3 NCBI NCBI:22849