CPEB3 - cytoplasmic polyadenylation element binding protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22849

About CPEB3

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:92,046,692-92,291,233 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 68 phenotypes. Broad expression in brain (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CPEB3 Products (2)

mRNA Protein Name
NM_001178137.2 NP_001171608.1 cytoplasmic polyadenylation element-binding protein 3 isoform 2
NM_014912.5 NP_055727.3 cytoplasmic polyadenylation element-binding protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
22730302 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
22711986 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20639532 GOA
enables translation factor activity, RNA binding IDA
IDA: Inferred from direct assay
22711986 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
21336257 GOA
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20639532 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20639532 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
22711986 GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
21336257 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
21336257 GOA
Cellular Component GO Annotation Evidence References Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
21336257 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20639532 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
22730302 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20639532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPEB3 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (443 - 504)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

cytoplasmic polyadenylation element-binding protein 3

  • CPE-BP3

CPEB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CPEB3 Q8NE35 TOB1 Homo sapiens P50616
Anti Tag CoIP
21336257
Intra
CPEB3 Q8NE35 TOB1 Homo sapiens P50616
Pull Down
21336257
Intra
CPEB3 Q8NE35 TOB1 Homo sapiens P50616
Anti Bait CoIP
21336257
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03093 CPEB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CPEB3 VGNC VGNC:71449
Mus musculus CPEB3 MGD MGI:2443075
Canis familiaris CPEB3 VGNC VGNC:39553
Bos taurus CPEB3 VGNC VGNC:27649
Rattus norvegicus CPEB3 RGD RGD:1564670
Others CPEB3 NCBI