Neurod1 - neurogenic differentiation 1 Gene

Also Known as Nd1; BETA2; BHF-1; Neurod; bHLHa3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18012

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including enteroendocrine cell differentiation; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study type 1 diabetes mellitus 7. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]

Neurod1 Products (1)

mRNA Protein Name
NM_010894.3 NP_035024.1 neurogenic differentiation factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12368292 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11981044 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
14697366 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11981044 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
18007592 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9512516 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15793245 MGI
Biological Process GO Annotation Evidence References Source
involved in amacrine cell differentiation IDA
IDA: Inferred from direct assay
11861467 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16368089 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
11861467 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
11861467 MGI
acts upstream of cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
18848628 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
10398678 MGI
acts upstream of or within dentate gyrus development IGI
IGI: Inferred from genetic interaction
10804213 MGI
involved in dentate gyrus development IMP
IMP: Inferred from mutant phenotype
10398678 MGI
involved in embryonic organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9308961 MGI
involved in endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
9308961 MGI
involved in enteroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
9308961 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
9308961 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
16368089 MGI
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
11152640 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
18848628 MGI
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9308961 MGI
acts upstream of or within pancreatic A cell fate commitment IGI
IGI: Inferred from genetic interaction
17988662 MGI
acts upstream of or within pancreatic PP cell fate commitment IGI
IGI: Inferred from genetic interaction
17988662 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14697366 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12368292 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14697366 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9512516 MGI
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
9512516 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
18007592 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15121856 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9512516 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15701640 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15793245 MGI
involved in regulation of intestinal epithelial structure maintenance IDA
IDA: Inferred from direct assay
9512516 MGI
acts upstream of or within regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
22513373 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15793245 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18388149 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10868931 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11891657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic differentiation factor 1

  • beta-cell E-box transcriptional activator 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09224 NEUROD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174573 Human NEUROD1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Neurod1 NCBI NCBI:4760