Neurod1 - neurogenic differentiation 1 Gene

Mus musculus

Also known as Nd1; BETA2; BHF-1; Neurod; bHLHa3

Gene ID: 18012 | Gene type: protein coding

About Neurod1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including enteroendocrine cell differentiation; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study type 1 diabetes mellitus 7. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]

Neurod1 Products(1)

mRNA	Protein	Name
NM_010894.3	NP_035024.1	neurogenic differentiation factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12368292	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11981044	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	14697366	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11981044	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18007592	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9512516	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15793245	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amacrine cell differentiation	IDA IDA: Inferred from direct assay	11861467	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16368089	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	11861467	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	11861467	MGI
acts upstream of cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	18848628	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	10398678	MGI
acts upstream of or within dentate gyrus development	IGI IGI: Inferred from genetic interaction	10804213	MGI
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	10398678	MGI
involved in embryonic organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9308961	MGI
involved in endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	9308961	MGI
involved in enteroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	9308961	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	9308961	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	16368089	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	11152640	MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	18848628	MGI
involved in negative regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9308961	MGI
acts upstream of or within pancreatic A cell fate commitment	IGI IGI: Inferred from genetic interaction	17988662	MGI
acts upstream of or within pancreatic PP cell fate commitment	IGI IGI: Inferred from genetic interaction	17988662	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14697366	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12368292	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14697366	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9512516	MGI
involved in positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	9512516	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18007592	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15121856	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9512516	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15701640	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15793245	MGI
involved in regulation of intestinal epithelial structure maintenance	IDA IDA: Inferred from direct assay	9512516	MGI
acts upstream of or within regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	22513373	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15793245	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18388149	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10868931	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11891657	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurogenic differentiation factor 1

beta-cell E-box transcriptional activator 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09224	NEUROD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174573	Human NEUROD1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Neurod1	NCBI	NCBI:4760

Name
Email *

	Sorry, but the email address you supplied was invalid.