Nrl - neural retina leucine zipper gene Gene

Also Known as D14H14S46E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18185

Summary

This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Nrl Products (4)

mRNA Protein Name
NM_001136074.3 NP_001129546.1 neural retina-specific leucine zipper protein
NM_001271916.2 NP_001258845.1 neural retina-specific leucine zipper protein
NM_001271917.2 NP_001258846.1 neural retina-specific leucine zipper protein
NM_008736.4 NP_032762.1 neural retina-specific leucine zipper protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15689355 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
11694879 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
15163632 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
15689355 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
15689355 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11694879 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15689355 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15689355 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15163632 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11694879 MGI
acts upstream of or within retinal rod cell development IMP
IMP: Inferred from mutant phenotype
11694879 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neural retina-specific leucine zipper protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-105047 Cholyl-Lys-fluorescein 98.14% Phase 3

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162596 NRL-1049 Inhibitor 99.96% Unkown
HY-126432 NRL-1049 dihydrochloride Inhibitor 99.20% Unkown
HY-RS16572 Lcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126432S (Rac)-NRL-1049-d5 dihydrochloride / Unkown
HY-162596A (Rac)-NRL-1049 dihydrochloride Inhibitor / Unkown
HY-RS09575 NRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N15829 Cholyl-Lys-fluorescein disodium / Unkown
HY-RS21286 Nrl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27805 Nrl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrl NCBI NCBI:4901