Pax4 - paired box 4 Gene

Also Known as Pax-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18506

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of cell differentiation. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; foregut-midgut junction; and urinary system. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4). [provided by Alliance of Genome Resources, Apr 2022]

Pax4 Products (3)

mRNA Protein Name
NM_001159925.1 NP_001153397.1 paired box protein Pax-4 isoform 2
NM_001159926.1 NP_001153398.1 paired box protein Pax-4 isoform 3
NM_011038.2 NP_035168.1 paired box protein Pax-4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10567552 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15930104 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15930104 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10567552 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15930104 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
14729487 MGI
acts upstream of or within regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
14970313 MGI
acts upstream of type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
14729487 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired box protein Pax-4

  • paired box gene 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10091 PAX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174559 Human PAX4 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pax4 NCBI NCBI:5078