Pla2g5 - phospholipase A2, group V Gene

Also Known as PLA2; sPLA2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18784

Summary

Enables Phospholipase A2 activity and signaling receptor binding activity. Involved in several processes, including arachidonic acid secretion; low-density lipoprotein particle remodeling; and positive regulation of immune effector process. Acts upstream of or within negative regulation of inflammatory response and regulation of macrophage activation. Located in cell surface; early phagosome; and phagolysosome. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (Phospholipase A2 group V). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g5 Products (2)

mRNA	Protein	Name
NM_001122954.1	NP_001116426.1	phospholipase A2 group V precursor
NM_011110.4	NP_035240.3	phospholipase A2 group V precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	11830583	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11830583	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate secretion	IDA IDA: Inferred from direct assay	11830583	MGI
involved in low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	14962950	MGI
acts upstream of or within low-density lipoprotein particle remodeling	IMP IMP: Inferred from mutant phenotype	24910243	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24910243	MGI
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	19342668	MGI
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	11830583	MGI
involved in positive regulation of antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	19342668	MGI
involved in positive regulation of immune complex clearance by monocytes and macrophages	IMP IMP: Inferred from mutant phenotype	20432503	MGI
involved in positive regulation of macrophage derived foam cell differentiation	IDA IDA: Inferred from direct assay	14962950	MGI
involved in positive regulation of opsonization	IMP IMP: Inferred from mutant phenotype	19342668	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	16407308	MGI
involved in positive regulation of phagosome maturation	IMP IMP: Inferred from mutant phenotype	19342668	MGI
acts upstream of or within regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	24910243	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8943302	MGI
located in early phagosome	IDA IDA: Inferred from direct assay	16407308	MGI
located in phagolysosome	IDA IDA: Inferred from direct assay	16407308	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phospholipase A2 group V	PLA2-10 calcium-dependent phospholipase A2 group V phospholipase A2 phosphatidylcholine 2-acylhydrolase 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10632	PLA2G5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184012	BAY-163	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g5	NCBI	NCBI:5322