Plxna1 - plexin A1 Gene

Also Known as NOV; Plxn1; PlexA1; mKIAA4053; 2600013D04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18844

Summary

Enables semaphorin receptor activity. Acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in membrane. Is expressed in several structures, including central nervous system; cranial nerve; genitourinary system; lung; and sensory organ. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Apr 2022]

Plxna1 Products (1)

mRNA Protein Name
NM_008881.2 NP_032907.1 plexin-A1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10520994 MGI
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
16715077 MGI
enables semaphorin receptor activity IPI
IPI: Inferred from physical interaction
15239958 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: Inferred from direct assay
16715077 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IDA
IDA: Inferred from direct assay
17626059 MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IGI
IGI: Inferred from genetic interaction
31690636 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
21835343 MGI
acts upstream of or within neuron projection guidance IMP
IMP: Inferred from mutant phenotype
21835343 MGI
involved in olfactory nerve formation IGI
IGI: Inferred from genetic interaction
31690636 MGI
acts upstream of or within regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
14977921 MGI
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
16715077 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31171447 MGI
located in membrane IDA
IDA: Inferred from direct assay
11241833 MGI
part of semaphorin receptor complex IDA
IDA: Inferred from direct assay
16715077 MGI
is active in synapse IDA
IDA: Inferred from direct assay
31171447 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plexin-A1

  • plex 1

  • plexin-1

Recombinant Plxna1 Proteins

Cat. No. Product Name Accession Purity
HY-P700813 PLXNA1 Protein, Mouse (HEK293, His) P70206 (S28-P1242) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10748 PLXNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19071 Plxna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25561 Plxna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plxna1 NCBI NCBI:5361