PLXNA1 Protein, Mouse (HEK293, His)

The PLXNA1 protein serves as a coreceptor and regulates signaling through SEMA3A, SEMA3C, SEMA3F, and SEMA6D, which is critical for cytoskeletal remodeling. It guides axons and promotes invasive growth and cell migration. PLXNA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLXNA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PLXNA1 Protein, Mouse (HEK293, His) is 1215 a.a., with molecular weight of 140-160 kDa.

PLXNA1 protein acts as a coreceptor for SEMA3A, SEMA3C, SEMA3F, and SEMA6D, playing a crucial role in signaling by class 3 semaphorins and subsequent cytoskeletal remodeling. It is involved in axon guidance, invasive growth, and cell migration. The binding of class 3 semaphorins to a complex composed of a neuropilin and PLXNA1 modulates the complex's affinity for specific semaphorins, and the cytoplasmic domain of PLXNA1 is essential for activating downstream signaling events. PLXNA1 directly interacts with NRP1, NRP2, FARP2, RND1, and KDR/VEGFR2, and SEMA3A binding leads to the dissociation of FARP2. Additionally, PLXNA1 interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3, and DPYSL4/CRMP4.

Mouse

HEK293

C-His

P70206 (S28-P1242)

18844  [NCBI]

140-160 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.