PLXNA1 Protein, Mouse (HEK293, His)
The PLXNA1 protein serves as a coreceptor and regulates signaling through SEMA3A, SEMA3C, SEMA3F, and SEMA6D, which is critical for cytoskeletal remodeling.It guides axons and promotes invasive growth and cell migration.PLXNA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLXNA1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The PLXNA1 protein serves as a coreceptor and regulates signaling through SEMA3A, SEMA3C, SEMA3F, and SEMA6D, which is critical for cytoskeletal remodeling.It guides axons and promotes invasive growth and cell migration.PLXNA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLXNA1 protein, expressed by HEK293 , with C-His labeled tag.
Background
PLXNA1 protein acts as a coreceptor for SEMA3A, SEMA3C, SEMA3F, and SEMA6D, playing a crucial role in signaling by class 3 semaphorins and subsequent cytoskeletal remodeling. It is involved in axon guidance, invasive growth, and cell migration. The binding of class 3 semaphorins to a complex composed of a neuropilin and PLXNA1 modulates the complex's affinity for specific semaphorins, and the cytoplasmic domain of PLXNA1 is essential for activating downstream signaling events. PLXNA1 directly interacts with NRP1, NRP2, FARP2, RND1, and KDR/VEGFR2, and SEMA3A binding leads to the dissociation of FARP2. Additionally, PLXNA1 interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3, and DPYSL4/CRMP4.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
P70206 (S28-P1242)
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Molecular Construction
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N-term
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PLXNA1 (S28-P1242)
Accession # P70206 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
PLXNA1; PLEXIN-A1; Prev. PLXN1; Plexin 1; NOV; DWOPNED; Semaphorin Receptor NOV; NOVP; Plexin A1; Plexin-A1
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AA Sequence
SPPAGLGPQPAFRTFVASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVREAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVNDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGQALAKQLGLAEDEEVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKEDGLTAVAAYDYQGRTVVFAGTRSGRIRKILVDLANPSGRPALAYESVVAQEGNPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERAEEPQRFASDLLQCVQLTVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTETESILEDGRIHCHSPSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRHVCTNNAADCAFLEGRVNMSEDCPQILPSTHIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVGKVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSIGGRPCSFSWRNSREIRCLTPPGHTPGSAPIVININRAQLSNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENSCMVYNDTTMVCRAPSIDNPKRSPPELGERPDEIGFIMDNVRTLLVLNSSSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCILTVSETQLLCEAPNLTGQHKVTVRAGGFEFSPGMLQVYSDSLLTLP
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Predicted Molecular Mass
134.9 kDa
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Molecular Weight
Approximately 140-160 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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