PLXNA1 - plexin A1 Gene

Homo sapiens

Also known as NOV; NOVP; PLXN1; DWOPNED; PLEXIN-A1

Gene ID: 5361 | Gene type: protein coding

About PLXNA1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,983,115-127,037,389 (from NCBI)

This gene has 5 transcripts (splice variants), 292 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 7.9), testis (RPKM 6.7) and 24 other tissues.

Summary

Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLXNA1 Products(1)

mRNA	Protein	Name
NM_032242.4	NP_115618.3	plexin-A1 precursor

PLXNA1 Protein Structure

Sema

PSI

TIG

Plexin_cytopl

0
300
600
900
1200
1500
1800
1896 a.a.

Protein Preferred Names

Protein Names

plexin-A1

plexin 1

Recombinant PLXNA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71646	PLXNA1 Protein, Human (His)	Q9UIW2 (986L-1152L)	≥95%
HY-P700812	PLXNA1 Protein, Human (HEK293, His)	Q9UIW2 (E27-P1244)	≥95%

Related Diseases

Diseases

Alias

Dworschak-Punetha Neurodevelopmental Syndrome

DWOPNED

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10748	PLXNA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLXNA1	VGNC	VGNC:44718
Bos taurus	PLXNA1	VGNC	VGNC:33059
Mus musculus	PLXNA1	MGD	MGI:107685
Rattus norvegicus	PLXNA1	RGD	RGD:1560871
Felis catus	PLXNA1	VGNC	VGNC:68914
Macaca mulatta	PLXNA1	VGNC	VGNC:76183
Others	PLXNA1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.