PLXNA1 - plexin A1 Gene

Also Known as NOV; NOVP; PLXN1; DWOPNED; PLEXIN-A1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5361

About PLXNA1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,983,115-127,037,389 (from NCBI)

This gene has 5 transcripts (splice variants), 292 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 7.9), testis (RPKM 6.7) and 24 other tissues.

Summary

Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLXNA1 Products (1)

mRNA Protein Name
NM_032242.4 NP_115618.3 plexin-A1 precursor

PLXNA1 Protein Structure

Sema

Sema: Sema domain (52 - 491)

PSI

PSI: Plexin repeat (514 - 559)

PSI

PSI: Plexin repeat (660 - 707)

PSI

PSI: Plexin repeat (809 - 861)

TIG

TIG: IPT/TIG domain (864 - 957)

TIG

TIG: IPT/TIG domain (961 - 1044)

TIG

TIG: IPT/TIG domain (1048 - 1110)

TIG

TIG: IPT/TIG domain (1166 - 1225)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1318 - 1866)

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  • 1896 a.a.
Protein Preferred Names Protein Names

plexin-A1

  • plexin 1

Recombinant PLXNA1 Proteins

Cat. No. Product Name Accession Purity
HY-P71646 PLXNA1 Protein, Human (His) Q9UIW2 (L986-L1152) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700812 PLXNA1 Protein, Human (HEK293, His) Q9UIW2 (E27-P1244) ≥ 95%, as determined by reducing SDS-PAGE.

PLXNA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81848 Plexin A1 Antibody (YA1593) WB, ICC/IF, FC Human, Mouse, Rat
HY-P84866 Plexin A1 Antibody (YA4563) ICC/IF, FC, ELISA Human
HY-P84866A Plexin A1 Antibody (YA4563)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Dworschak-Punetha Neurodevelopmental Syndrome

  • DWOPNED
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10748 PLXNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19071 Plxna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25561 Plxna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLXNA1 VGNC VGNC:44718
Bos taurus PLXNA1 VGNC VGNC:33059
Mus musculus PLXNA1 MGD MGI:107685
Rattus norvegicus PLXNA1 RGD RGD:1560871
Felis catus PLXNA1 VGNC VGNC:68914
Macaca mulatta PLXNA1 VGNC VGNC:76183
Others PLXNA1 NCBI