Pou3f1 - POU class 3 homeobox 1 Gene

Rattus norvegicus

Also known as Otf6; Scip; Oct-6; Tst-1; Testes-1

Gene ID: 192110 | Gene type: protein coding

About Pou3f1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in glial cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human POU3F1 (POU class 3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f1 Products(1)

mRNA	Protein	Name
NM_138838.2	NP_620193.1	POU domain, class 3, transcription factor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9196379	RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9632656	RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1705013	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1705013	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9196379	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glial cell differentiation	IDA IDA: Inferred from direct assay	1975954	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1975954	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1705013	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9632656	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9632656	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9196379	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

POU domain, class 3, transcription factor 1

OTF-6	POU domain transcription factor SCIP
octamer-binding protein 6	octamer-binding transcription factor 6
octoamer transcription factor-6	octomer-6
suppressed cAMP-inducible POU

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10900	POU3F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou3f1	NCBI	NCBI:5453

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