Ptprn2 - protein tyrosine phosphatase, receptor type, N polypeptide 2 Gene

Also Known as Phol; PTP-NP; IA2beta; phogrin; mKIAA0387; 4930425H11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19276

Summary

Predicted to enable protein tyrosine Phosphatase activity. Involved in Insulin secretion involved in cellular response to glucose stimulus and neurotransmitter secretion. Located in secretory granule membrane and synaptic vesicle membrane. Is expressed in several structures, including foregut-midgut junction; midgut endoderm; and nervous system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine Phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]

Ptprn2 Products (1)

mRNA Protein Name
NM_011215.2 NP_035345.2 receptor-type tyrosine-protein phosphatase N2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12364328 MGI
Biological Process GO Annotation Evidence References Source
involved in insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21732083 MGI
involved in neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
19361477 MGI
Cellular Component GO Annotation Evidence References Source
located in secretory granule IDA
IDA: Inferred from direct assay
15788565 MGI
located in secretory granule membrane IDA
IDA: Inferred from direct assay
19361477 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
19361477 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase N2

  • IA-2 beta

  • PTP IA-2beta

  • R-PTP-N2

  • protein tyrosine phosphatase-NP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprn2 NCBI NCBI:5799