Rasgrf1 - RAS protein-specific guanine nucleotide-releasing factor 1 Gene

Also Known as Gnrp; Grf1; p190; CDC25; P190-A; CDC25Mm; Grfbeta; Ras-GRF1; p190RhoGEF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19417

Summary

Enables glutamate receptor binding activity. Involved in activation of GTPase activity; neuron projection development; and regulation of Rac protein signal transduction. Acts upstream of or within cell population proliferation; regulation of NMDA Receptor activity; and regulation of neuronal synaptic plasticity. Located in cytosol and growth cone. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rasgrf1 Products (4)

mRNA Protein Name
NM_001039655.1 NP_001034744.1 ras-specific guanine nucleotide-releasing factor 1 isoform 2
NM_001357743.1 NP_001344672.1 ras-specific guanine nucleotide-releasing factor 1 isoform 3
NM_001357744.1 NP_001344673.1 ras-specific guanine nucleotide-releasing factor 1 isoform 4
NM_011245.2 NP_035375.1 ras-specific guanine nucleotide-releasing factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
16710293 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17135267 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
17135267 MGI
involved in neuron projection development IDA
IDA: Inferred from direct assay
17135267 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17135267 MGI
acts upstream of or within regulation of NMDA receptor activity IGI
IGI: Inferred from genetic interaction
15029245 MGI
involved in regulation of Rac protein signal transduction IDA
IDA: Inferred from direct assay
17135267 MGI
involved in regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
17135267 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11749043 MGI
acts upstream of or within type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
12805218 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17135267 MGI
located in growth cone IDA
IDA: Inferred from direct assay
17135267 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-specific guanine nucleotide-releasing factor 1

  • Ras guanine release factor beta

  • ras-specific nucleotide exchange factor CDC25

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11691 RASGRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rasgrf1 NCBI NCBI:5923