Rasgrf1 - RAS protein-specific guanine nucleotide-releasing factor 1 Gene

Mus musculus

Also known as Gnrp; Grf1; p190; CDC25; P190-A; CDC25Mm; Grfbeta; Ras-GRF1; p190RhoGEF

Gene ID: 19417 | Gene type: protein coding

About Rasgrf1

Summary

Enables glutamate receptor binding activity. Involved in activation of GTPase activity; neuron projection development; and regulation of Rac protein signal transduction. Acts upstream of or within cell population proliferation; regulation of NMDA Receptor activity; and regulation of neuronal synaptic plasticity. Located in cytosol and growth cone. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rasgrf1 Products(4)

mRNA	Protein	Name
NM_001039655.1	NP_001034744.1	ras-specific guanine nucleotide-releasing factor 1 isoform 2
NM_001357743.1	NP_001344672.1	ras-specific guanine nucleotide-releasing factor 1 isoform 3
NM_001357744.1	NP_001344673.1	ras-specific guanine nucleotide-releasing factor 1 isoform 4
NM_011245.2	NP_035375.1	ras-specific guanine nucleotide-releasing factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	16710293	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17135267	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	17135267	MGI
involved in neuron projection development	IDA IDA: Inferred from direct assay	17135267	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17135267	MGI
acts upstream of or within regulation of NMDA receptor activity	IGI IGI: Inferred from genetic interaction	15029245	MGI
involved in regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	17135267	MGI
involved in regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	17135267	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11749043	MGI
acts upstream of or within type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	12805218	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17135267	MGI
located in growth cone	IDA IDA: Inferred from direct assay	17135267	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-specific guanine nucleotide-releasing factor 1

Ras guanine release factor beta

ras-specific nucleotide exchange factor CDC25

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11691	RASGRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rasgrf1	NCBI	NCBI:5923

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