Rit2 - Ras-like without CAAX 2 Gene

Also Known as Rin; RIBA; Roc2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19762

Summary

Enables several functions, including GTP binding activity; GTPase activity; and Calmodulin binding activity. Involved in several processes, including Ras protein signal transduction; regulation of Cdc42 protein signal transduction; and regulation of neuron projection development. Located in several cellular components, including cell body; dendritic tree; and nucleus. Is expressed in central nervous system; lung; and neural retina. Orthologous to human RIT2 (Ras like without CAAX 2). [provided by Alliance of Genome Resources, Apr 2022]

Rit2 Products (1)

mRNA	Protein	Name
NM_009065.2	NP_033091.1	GTP-binding protein Rit2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	8824319	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	10545207	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	8824319	MGI
enables calmodulin binding	IPI IPI: Inferred from physical interaction	14662747	MGI
enables chromatin binding	IGI IGI: Inferred from genetic interaction	12934100	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10545207	MGI

Biological Process GO Annotation	Evidence	References	Source
NOT involved in MAPK cascade	IDA IDA: Inferred from direct assay	14662747	MGI
involved in Ras protein signal transduction	IDA IDA: Inferred from direct assay	11877426	MGI
involved in Ras protein signal transduction	IGI IGI: Inferred from genetic interaction	11877426	MGI
involved in negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	14662747	MGI
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	14662747	MGI
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	11877426	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12934100	MGI
involved in regulation of Cdc42 protein signal transduction	IDA IDA: Inferred from direct assay	14662747	MGI
NOT involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11877426	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	23805044	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12934100	MGI
located in dendritic tree	IDA IDA: Inferred from direct assay	23805044	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12934100	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8824319	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
GTP-binding protein Rit2	GTP-binding protein Roc2 RAS-like protein expressed in neuron ras-like protein expressed in neurons ras-like without CAAX protein 2

Rit2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Rit2	P70425	RLF	Homo sapiens	Q13129	Pull Down	10545207
Cross	Rit2	P70425	RLF	Homo sapiens	Q13129	Y2H	10545207

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12004	RIT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rit2	NCBI	NCBI:6014