Sema4b - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Gene

Also Known as SemC; Semac; sema C; mKIAA1745

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20352

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within cell differentiation and nervous system development. Located in plasma membrane and synapse. Is expressed in several structures, including back musculature; central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human SEMA4B (semaphorin 4B). [provided by Alliance of Genome Resources, Apr 2022]

Sema4b Products (2)

mRNA Protein Name
NM_001360135.2 NP_001347064.1 semaphorin-4B precursor
NM_013659.5 NP_038687.2 semaphorin-4B precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15978582 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15978582 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15978582 MGI
located in membrane IDA
IDA: Inferred from direct assay
15978582 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15978582 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
15978582 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
15978582 MGI
located in synapse IDA
IDA: Inferred from direct assay
15978582 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-4B

  • semaphorin-C

Recombinant Sema4b Proteins

Cat. No. Product Name Accession Purity
HY-P78034 Semaphorin-4B/SEMA4B Protein, Mouse (HEK293, His) Q62179 (L31-E703) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12658 SEMA4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18569 Sema4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25053 Sema4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema4b NCBI NCBI:10509