Semaphorin-4B/SEMA4B Protein, Mouse (HEK293, His)
Semaphorin-4B (SEMA4B) protein inhibits axonal extension by emitting local signals that define inaccessible territories for growing axons.It interacts with the GIPC PDZ domain, regulating axonal guidance and territorial specificity during neural development.Semaphorin-4B/SEMA4B Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-4B/SEMA4B protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Semaphorin-4B (SEMA4B) protein inhibits axonal extension by emitting local signals that define inaccessible territories for growing axons.It interacts with the GIPC PDZ domain, regulating axonal guidance and territorial specificity during neural development.Semaphorin-4B/SEMA4B Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-4B/SEMA4B protein, expressed by HEK293 , with C-His labeled tag.
Background
Semaphorin-4B (SEMA4B) protein plays a crucial role in inhibiting axonal extension by emitting local signals that define territories as inaccessible for growing axons. Its mechanism involves interaction with the GIPC PDZ domain, contributing to the regulation of axonal guidance and territorial specificity during neural development.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
Q62179 (L31-E703)
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Molecular Construction
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N-term
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SEMA4B (L31-E703)
Accession # Q62179 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
SEMA4B; Semaphorin-4B; Prev. SEMAC; MGC131831; KIAA1745; Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, 4B; SemC; SEMA4B Protein; Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Shor
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AA Sequence
LGPRISVPLGSEERLIRKFEAENISNYTALLLSQDGKTLYVGAREALFALNSNLSFLPGGEYQELLWSADADRKQQCSFKGKDPKRDCQNYIKILLPLNSSHLLTCGTAAFSPLCAYIHIASFTLAQDEAGNVILEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSSRPTKTESSLNWLQDPAFVASAYVPESLGSPIGDDDKIYFFFSETGQEFEFFENTIVSRVARVCKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLNPNPQDWRKTLFYGVFTSQWHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWYTETHQVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVRSRLLLLQPRARYQRVAVHRVPGLHSTYDVLFLGTGDGRLHKAVTLSSRVHIIEELQIFPQGQPVQNLLLDSHGGLLYASSHSGVVQVPVANCSLYPTCGDCLLARDPYCAWTGSACRLASLYQPDLASRPWTQDIEGASVKELCKNSSYKARFLVPGKPCKQVQIQPNTVNTLACPLLSNLATRLWVHNGAPVNASASCRVLPTGDLLLVGSQQGLGVFQCWSIEEGFQQLVASYCPEVMEEGVMDQKNQRDGTPVIINTSRVSAPAGGRASWGADKSYWNE
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Predicted Molecular Mass
75.7 kDa
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Molecular Weight
Approximately 78-83 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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