Sh2b1 - SH2B adaptor protein 1 Gene

Also Known as Psm; Irip; SH2-B; SH2-Bb; Sh2bpsm1; mKIAA1299; C530001K22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20399

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Involved in positive regulation of mitotic nuclear division and regulation of DNA biosynthetic process. Acts upstream of or within lamellipodium assembly. Predicted to be located in cytosol and ruffle. Predicted to be active in plasma membrane. Is expressed in dorsal aorta. Orthologous to human SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh2b1 Products (7)

mRNA Protein Name
NM_001081459.2 NP_001074928.1 SH2B adapter protein 1 isoform 1
NM_001289538.1 NP_001276467.1 SH2B adapter protein 1 isoform 4
NM_001289539.1 NP_001276468.1 SH2B adapter protein 1 isoform 1
NM_001289540.1 NP_001276469.1 SH2B adapter protein 1 isoform 1
NM_001289541.1 NP_001276470.1 SH2B adapter protein 1 isoform 3
NM_001289542.1 NP_001276471.1 SH2B adapter protein 1 isoform 3
NM_011363.3 NP_035493.2 SH2B adapter protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10644978 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell motility IDA
IDA: Inferred from direct assay
11786545 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
11786545 MGI
involved in positive regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
10644978 MGI
involved in regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
10644978 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2B adapter protein 1

  • SH2 domain-containing protein 1B

  • SH2-B PH domain containing signaling mediator 1

  • pro-rich, PH and SH2 domain-containing signaling mediator

Sh2b1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh2b1 Q91ZM2 Jak2 Mus musculus Q62120
X-Ray Diffraction
16824542
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12818 SH2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2b1 NCBI NCBI:25970