St8sia2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Gene

Mus musculus

Also known as STX; Siat8b; ST8SiaII

Gene ID: 20450 | Gene type: protein coding

About St8sia2

Summary

Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and neuron projection extension. Located in early endosome and recycling endosome. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

St8sia2 Products(1)

mRNA	Protein	Name
NM_009181.2	NP_033207.2	alpha-2,8-sialyltransferase 8B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IDA IDA: Inferred from direct assay	7782326	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20479255	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in sialylation	IDA IDA: Inferred from direct assay	7782326	MGI
involved in sialylation	IMP IMP: Inferred from mutant phenotype	27534376	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	23303939	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23303939	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-2,8-sialyltransferase 8B

SIAT8-B	polysialic acid synthase
sialyltransferase 8 (alpha-2, 8-sialyltransferase) B	sialyltransferase 8B
sialyltransferase St8Sia II	sialyltransferase X
sialytransferase St8Sia II

St8sia2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	St8sia2	O35696	CADM1	Homo sapiens	Q9BY67	Glycosylase Assay	20479255

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13857	ST8SIA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	St8sia2	NCBI	NCBI:8128

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