Ro60 - Ro60, Y RNA binding protein Gene

Also Known as Ssa; Ssa2; Trove2; SS-A/Ro; 1810007I17Rik; A530054J02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20822

Summary

Enables U2 snRNA binding activity. Acts upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in embryo. Used to study systemic lupus erythematosus. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Ro60 Products (1)

mRNA Protein Name
NM_013835.2 NP_038863.1 RNA-binding protein Ro60

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
14680639 MGI
enables U2 snRNA binding IDA
IDA: Inferred from direct assay
14680639 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
21289087 MGI
acts upstream of or within immune system development IMP
IMP: Inferred from mutant phenotype
12788971 MGI
acts upstream of or within response to UV IDA
IDA: Inferred from direct assay
14680639 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
12788971 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21289087 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14680639 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14680639 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
14680639 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA-binding protein Ro60

60 kDa SS-A/Ro ribonucleoprotein

  • 60 kDa Ro protein

  • 60 kDa ribonucleoprotein Ro

  • Sjogren syndrome antigen A2

  • TROVE domain family, member 2

  • roRNP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123838 Ro60-0175 Agonist 99.52% Unkown
HY-103140 Ro60-0175 fumarate Agonist 99.47% Unkown
HY-RS12109 RO60 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ro60 NCBI NCBI:6738