Swap70 - SWA-70 protein Gene

Also Known as 70kDa

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20947

Summary

Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; negative regulation of peptidyl-serine dephosphorylation; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Apr 2022]

Swap70 Products (1)

mRNA	Protein	Name
NM_009302.3	NP_033328.3	switch-associated protein 70

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9642267	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	9642267	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17403664	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	23921380	MGI
acts upstream of or within isotype switching	IDA IDA: Inferred from direct assay	9642267	MGI
involved in negative regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	23921380	MGI
involved in negative regulation of cell-cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	15542837	MGI
involved in positive regulation of actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	23921380	MGI
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15542837	MGI
involved in positive regulation of mast cell chemotaxis	IMP IMP: Inferred from mutant phenotype	15542837	MGI
involved in regulation of actin polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	15542837	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	15542837	MGI
acts upstream of or within somatic cell DNA recombination	IDA IDA: Inferred from direct assay	9642267	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9642267	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
switch-associated protein 70	SWAP complex protein, 70 kDa SWAP-70

Swap70 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Swap70	Q6A028	Itga7	Mus musculus	Q61738-6	Y2H	17403664
Intra	Swap70	Q6A028	Itga7	Mus musculus	Q61738-6	Anti Tag CoIP	17403664

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14063	SWAP70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Swap70	NCBI	NCBI:23075