SWAP70 - switching B cell complex subunit SWAP70 Gene

Also Known as HSPC321; SWAP-70

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23075

About SWAP70

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,664,077-9,752,993 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 33.7), spleen (RPKM 30.6) and 24 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SWAP70 Products (2)

mRNA Protein Name
NM_001297714.2 NP_001284643.1 switch-associated protein 70 isoform 2
NM_015055.4 NP_055870.2 switch-associated protein 70 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
30123108 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
30123108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SWAP70 Protein Structure

PH

PH: PH domain (212 - 305)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

switch-associated protein 70

  • SWAP switching B-cell complex 70kDa subunit

SWAP70 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SWAP70 Q9UH65 ZBTB5 Homo sapiens O15062
Y2H Prey Pooling
25416956
Intra
SWAP70 Q9UH65 ZBTB5 Homo sapiens O15062
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

SWAP70 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81328 Switch Associated Protein 70 Antibody (YA1073) WB, IP Human, Mouse, Rat, Monkey
HY-P81328A Switch Associated Protein 70 Antibody (YA1073)(PBS only) WB, IP Human, Mouse, Rat, Monkey
HY-P85565 Switch Associated Protein 70 Antibody (YA5257) WB, IP Human, Mouse, Rat, Monkey

Related Diseases

Diseases Alias
Aleutian Mink Disease

  • Aleutian Disease
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14063 SWAP70 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SWAP70 VGNC VGNC:78142
Felis catus SWAP70 VGNC VGNC:65867
Bos taurus SWAP70 VGNC VGNC:54893
Canis familiaris SWAP70 VGNC VGNC:47009
Rattus norvegicus SWAP70 RGD RGD:1305579
Mus musculus SWAP70 MGD MGI:1298390
Others SWAP70 NCBI