Switch Associated Protein 70 Antibody (YA5257)
(Synonyms: KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN.)Switch Associated Protein 70 Antibody (YA5257) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Switch Associated Protein 70.
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Host:
Mouse
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat, Monkey
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
Switch Associated Protein 70 Antibody (YA5257) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Switch Associated Protein 70.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat, Monkey
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Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human SWAP70 protein fragments expressed in E.coli.
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Switch Associated Protein 70 is a Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
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Subcellular Localization
Cytoplasm; Cell membrane; Nucleus; Cell projection, lamellipodium; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:It is expressed only in mature B cells, including B cells associated with mucosa-associated tissues and bronchus-associated tissues (PubMed: 10681448) . It is widely expressed. It is abundant in the spleen, and also present in high concentrations in the kidneys, lungs, and liver. It has also been found in monocytes and macrophages (PubMed: 12925760) . -
Subunit
The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70
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SwissProt ID
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Synonyms
KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN.
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