Vamp7 - vesicle-associated membrane protein 7 Gene

Also Known as Sybl1; VAMP-7; TI-VAMP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20955

Summary

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly and positive regulation of dendrite morphogenesis. Acts upstream of or within Golgi to plasma membrane protein transport and regulation of protein targeting to vacuolar membrane. Located in several cellular components, including cytoplasmic vesicle; lamellipodium; and pseudopodium. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Vamp7 Products (3)

mRNA	Protein	Name
NM_001302138.2	NP_001289067.1	vesicle-associated membrane protein 7 isoform 2
NM_001359151.2	NP_001346080.1	vesicle-associated membrane protein 7 isoform 3
NM_011515.6	NP_035645.1	vesicle-associated membrane protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20871593	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	20582536	MGI
involved in SNARE complex assembly	IDA IDA: Inferred from direct assay	21151919	MGI
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22171327	MGI
acts upstream of or within regulation of protein targeting to vacuolar membrane	IMP IMP: Inferred from mutant phenotype	18227281	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18321981	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	14758363	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21151919	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	22589474	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	19745841	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18321981	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	15470500	MGI
located in pseudopodium	IDA IDA: Inferred from direct assay	22589474	MGI
located in transport vesicle	IDA IDA: Inferred from direct assay	19745841	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
vesicle-associated membrane protein 7	synaptobrevin like 1 tetanus neurotoxin-insensitive vesicle-associated membrane protein

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15598	VAMP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp7	NCBI	NCBI:6845