VAMP7 - vesicle associated membrane protein 7 Gene

Also Known as SYBL1; TIVAMP; VAMP-7; TI-VAMP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6845

About VAMP7

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,881,345-155,943,769 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 18.0), kidney (RPKM 17.3) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

VAMP7 Products (3)

mRNA	Protein	Name
NM_001145149.3	NP_001138621.1	vesicle-associated membrane protein 7 isoform 2
NM_001185183.2	NP_001172112.1	vesicle-associated membrane protein 7 isoform 3
NM_005638.6	NP_005629.1	vesicle-associated membrane protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16354670	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23217709	GOA
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	10888671	GOA
involved in eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	18042464	GOA
involved in neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in vesicle fusion	IDA IDA: Inferred from direct assay	10888671	GOA
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	10888671	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	18253931	GOA
located in azurophil granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18253931	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	22589474	GOA
located in membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18253931	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	22589474	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	22589474	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	18042464	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19745841	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP7 Protein Structure

Longin

Synaptobrevin

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
vesicle-associated membrane protein 7	synaptobrevin-like 1

VAMP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VAMP7	P51809	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
Intra	VAMP7	P51809	SNAP47	Homo sapiens	Q5SQN1	Pull Down	26359495
Cross	VAMP7	P51809	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	34706264
Cross	VAMP7	P51809	ap3a_sars2	SARS-CoV-2	P0DTC3	Confocal	34706264
Intra	VAMP7	P51809	AGFG1	Homo sapiens	P52594	Y2H	18775314
Intra	VAMP7	P51809	AGFG1	Homo sapiens	P52594	ITC	18775314

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw
46,Xy Partial Gonadal Dysgenesis	46,Xy Pgd 46,Xy Partial Testicular Dysgenesis
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf
Deafness, Y-Linked 2	DFNY2 Y-Linked Deafness 2
Mesenteric Lymphadenitis	Mesenteric Adenitis
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome	Cednik Syndrome CEDNIK Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Neurocutaneous Syndromes
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15598	VAMP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VAMP7	VGNC	VGNC:48226
Felis catus	VAMP7	VGNC	VGNC:66913
Bos taurus	VAMP7	VGNC	VGNC:107020
Macaca mulatta	VAMP7	VGNC	VGNC:78558
Rattus norvegicus	VAMP7	RGD	RGD:621558
Mus musculus	VAMP7	MGD	MGI:1096399
Others	VAMP7	NCBI