Syn2 - synapsin II Gene

Also Known as 2900074L19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20965

Summary

Enables identical protein binding activity. Involved in calcium-ion regulated exocytosis and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion. Located in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic vesicle membrane. Part of SNARE complex. Is expressed in several structures, including central nervous system; eye; intercostal muscle; nerve; and reproductive system. Used to study autism spectrum disorder and epilepsy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Apr 2022]

Syn2 Products (3)

mRNA Protein Name
NM_001111015.1 NP_001104485.1 synapsin-2 isoform IIa
NM_001326560.1 NP_001313489.1 synapsin-2 isoform IIc
NM_013681.3 NP_038709.1 synapsin-2 isoform IIb

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15071120 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18535671 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium-ion regulated exocytosis IMP
IMP: Inferred from mutant phenotype
20338242 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
7777057 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
7777057 MGI
involved in synaptic vesicle clustering IDA
IDA: Inferred from direct assay
18945891 MGI
involved in synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
18945891 MGI
involved in synaptic vesicle cycle IDA
IDA: Inferred from direct assay
7777057 MGI
involved in synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
7777057 MGI
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18535671 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
7777057 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
7777057 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18945891 MGI
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
25429150 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18945891 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18535671 MGI
is active in plasma membrane IPI
IPI: Inferred from physical interaction
18535671 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in synapse IDA
IDA: Inferred from direct assay
15071120 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
15071120 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synapsin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14080 SYN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18975 Stx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syn2 NCBI NCBI:6854