2. Gene
  3. Xist - inactive X specific transcripts Gene

Xist - inactive X specific transcripts Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as A430022B11

Gene ID: 213742 | Gene type: ncRNA

About Xist

Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
21172659 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within inactivation of paternal X chromosome by genomic imprinting IGI
IGI: Inferred from genetic interaction
15992549 MGI
acts upstream of or within inactivation of paternal X chromosome by genomic imprinting IMP
IMP: Inferred from mutant phenotype
22573614 MGI
acts upstream of or within random inactivation of X chromosome IDA
IDA: Inferred from direct assay
27892467 MGI
acts upstream of or within random inactivation of X chromosome IGI
IGI: Inferred from genetic interaction
12419249 MGI
acts upstream of or within spongiotrophoblast differentiation IMP
IMP: Inferred from mutant phenotype
22573614 MGI
Cellular Component GO Annotation Evidence Reference Source
located in X chromosome IDA
IDA: Inferred from direct assay
24613346 MGI
located in chromosome IDA
IDA: Inferred from direct assay
12419249 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
25145264 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22482507 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152038 SPEN-IN-1 Inhibitor 97.25% Unkown
HY-RS16461 XIST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16326 XIC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28885 XIST Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xist NCBI NCBI:7503