Cdc73 - cell division cycle 73, Paf1/RNA polymerase II complex component Gene

Also Known as Hrpt2; 8430414L16Rik; C130030P16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214498

Summary

Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Apr 2022]

Cdc73 Products (1)

mRNA Protein Name
NM_145991.2 NP_666103.1 parafibromin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22252316 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17911113 MGI
involved in endodermal cell fate commitment IMP
IMP: Inferred from mutant phenotype
19345177 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18212049 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19345177 MGI
acts upstream of or within regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18212049 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18212049 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19345177 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

parafibromin

  • cell division cycle protein 73 homolog

  • hyperparathyroidism 2 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02310 CDC73 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc73 NCBI NCBI:79577