F5 - coagulation factor V Gene

Also Known as FVL; PCCF; THPH2; RPRGL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2153

About F5

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,511,951-169,586,481 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues, 35 paralogues and is associated with 10 phenotypes. Biased expression in liver (RPKM 48.1), placenta (RPKM 23.5) and 2 other tissues.

Summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by Thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to Thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

F5 Products (1)

mRNA	Protein	Name
NM_000130.5	NP_000121.2	coagulation factor V preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	2844223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F5 Protein Structure

Cu-oxidase_3

F5_F8_type_C

0
400
800
1200
1600
2000
2224 a.a.

Protein Preferred Names	Protein Names
coagulation factor V	activated protein c cofactor

F5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89635	Factor V Antibody (YA8979)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Factor V Deficiency	Parahemophilia Labile Factor Deficiency Proaccelerin Deficiency Owren Disease Owren Parahemophilia Quebec Platelet Disorder Deficiency, Labile Hereditary Hypoproaccelerinaemia Owren'S Disease Congenital Factor V Deficiency FA5D Factor 5 Deficiency Deficiency, Factor V
Thrombophilia Due To Activated Protein C Resistance	Activated Protein C Resistance Apc Resistance THPH2 Thrombophilia Due To Deficiency Of Activated Protein C Cofactor Proc Cofactor Deficiency Pccf Deficiency Thrombophilia V Thrombophilia, Susceptibility To, Due To Factor V Leiden Thrombophilia Due To Factor V Leiden Thrombophilia 2 Due To Activated Protein C Resistance Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Pregnancy Loss, Recurrent 1	Pregnancy Loss, Recurrent, Susceptibility To, 1 Rpl RPRGL1 Rprgl Recurrent Miscarriage Recurrent Spontaneous Abortion Abortion, Spontaneous, Recurrent Fetal Loss, Recurrent Fetal Loss, Recurrent, Susceptibility To Miscarriage, Recurrent Embryonic Loss, Recurrent Stillbirth, Recurrent Pregnancy Loss, Recurrent, 1 Recurrent Embryonic Loss Recurrent Fetal Loss Recurrent Stillbirth Spontaneous Recurrent Abortion Miscarriage Recurrent Pregnancy Loss, Recurrent, Susceptibility To, Type 1 Abortion, Habitual
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Factor V Leiden Thrombophilia	Hereditary Resistance To Activated Protein C Apc Resistance, Leiden Type Thrombophilia Due To Activated Protein C Resistance
Bleeding Disorder, East Texas Type	Bdet East Texas Bleeding Disorder
Thrombophilia	Hypercoagulability State
Protein C Deficiency	Hereditary Thrombophilia Due To Protein C Deficiency Proc Deficiency Congenital Thrombotic Disease, Due To Protein C Deficiency
Antithrombin Iii Deficiency	Hereditary Antithrombin Deficiency Congenital Antithrombin Iii Deficiency Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency AT3D Thrombophilia Due To Antithrombin Iii Deficiency Thph7 Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency Thrombophilia 7 Due To Antithrombin Iii Deficiency At Iii Deficiency Congenital At-Iii Deficiency Inherited Antithrombin Deficiency Antithrombin 3 Deficiency Antithrombin Deficiency Antithrombin-Iii Deficiency At-Iii Deficiency Thrombophilia Due To Antithrombin-Iii Deficiency
Cerebral Sinovenous Thrombosis	Csvt
Thrombosis	Thrombosis Of Blood Vessel
Protein S Deficiency	Protein S Deficiency Disease Hereditary Thrombophilia Due To Protein S Deficiency
Portal Vein Thrombosis	Phlebitis Of Portal Vein Deep Vein Thrombosis Of Portal Vein Portal Thrombosis Pvt - [Portal Vein Thrombosis] Portal Venous Thrombosis Portal Venous Embolism Portal Venous Obstruction Portal Venous Block Portal Vein Embolism Portal Vein Block Portal Obstruction Portal Embolism Portal Block Hepatic Portal Vein Obstruction Occlusion Of Hepatic Portal Vein Portal Vein Obstruction
Retinal Vein Occlusion	Occlusion, Of Retinal Vein
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Antiphospholipid Syndrome	Antiphospholipid Antibody Syndrome Hughes Syndrome Familial Antiphospholipid Syndrome Aps Lupus Anticoagulant, Familial Anti-Phospholipid Syndrome Apls Classic Apls Classic Antiphospholipid Syndrome Acromegaloid Facial Appearance Syndrome Anticardiolipin Syndrome
Nonarteritic Anterior Ischemic Optic Neuropathy	Anterior Ischemic Optic Neuropathy Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To NAION Non-Arteritic Anterior Ischemic Optic Neuropathy Ischemic Optic Neuropathy Aion Optic Neuropathy, Ischemic Naion, Susceptibility To Optic Neuropathy, Anterior Ischemic Optic Neuropathy, Anterior Ischemic, Susceptibility To Non-Arteritic Anterior Ischaemic Optic Neuropathy Nonarteritic Anterior Ischaemic Optic Neuropathy Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To Ion - [Ischemic Optic Neuropathy] Neuropathic Ischaemia Of N.Opticus Ischaemic Neuropathy Of Optic Nerve
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Intracranial Thrombosis	Cerebral Thrombosis Thrombosis Of Cerebral Veins Cerebral Arterial Thrombosis
Factor Xii Deficiency	Hageman Factor Deficiency Haf Deficiency Factor Xii Deficiency Disease F12 Deficiency Deficiency, Hageman Coagulation Factor 12 Deficiency Factor 12 Deficiency Congenital Factor Xii Deficiency Congenital Hageman Factor Deficiency FA12D Factor Xii Deficiency, Factor Xii
Retinal Vascular Occlusion	Retinal Vasc. Occlusion Occlusion Of Retinal Vessels Retinal Obstruction
Central Retinal Vein Occlusion	Crvo
Amaurosis Fugax	Transient Monocular Blindness Momentary Blindness Af - [Amaurosis Fugax] Transient Vision Loss, Spontaneous Amaurosis Fugax, Course Of Resolution Unspecified
Homocysteinemia	Hyperhomocysteinemia
Post-Thrombotic Syndrome	Postphlebitic Syndrome Postthrombotic Syndrome Postphlebetic Syndrome With Inflammation Postphlebetic Syndrome With Ulcer Postphlebetic Syndrome With Ulcer And Inflammation Venous Stress Disorder
Hyperhomocysteinemia
Placental Abruption	Abruptio Placentae Abruptio Placenta Abortion, Threatened Threatened Miscarriage Haemorrhage Specified As Due To Threatened Abortion Spontaneous Threatened Abortion
Quebec Platelet Disorder	Factor V Quebec QPD Bdplt5 Bleeding Disorder, Platelet-Type, 5 Platelet-Type Bleeding Disorder 5 Bleeding Disorder Platelet-Type 5 Platelet Disorder, Quebec
Hellp Syndrome	Hemolysis, Elevated Liver Enzymes, Lowered Platelets Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet] Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Purpura Fulminans	Purpura Gangrenosa
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Placenta Disease	Placenta Diseases Placenta Disorder Pregnancy Complications Placenta Disorders
Mediastinitis
Homocystinuria	Cystathionine Beta Synthase Deficiency Homocysteinemia Cbs Deficiency Cystathionine Synthase Deficiency Cystathionine Beta-Synthase Deficiency Disease
Thrombophlebitis	Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities Superficial Thrombophlebitis Of Leg Thrombophlebitis Of A Superficial Leg Vein Thrombophlebitis Of Superficial Veins Of Lower Extremity
Factor V And Factor Viii, Combined Deficiency Of, 2	Factor V And Factor Viii, Combined Deficiency Of F5F8D2 Combined Deficiency Of Factor V And Factor Viii F5f8d Factor 5 And Factor Viii, Combined Deficiency Of, 2 Fv And Fviii Combined Deficiency Factor V And Factor Viii Combined Deficiency 2 Mcfd2 Multiple Coagulation Factor Deficiency 2 Deficiency, Combined, Factor V And Factor Viii, Type 2
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Acanthamoeba Keratitis
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Sneddon Syndrome	Livedo Reticularis And Cerebrovascular Accidents SNDNS Ehrmann-Sneddon Syndrome Livedo Racemosa-Cerebrovascular Accident Syndrome Livedo Reticularis-Cerebrovascular Accident Syndrome Sneddon'S Syndrome Idiopathic Livedo Reticularis With Systemic Involvement Cerebro-Vascular Lesions And Livedo Reticularis Livedo Racemosa And Cerebrovascular Accidents
Severe Pre-Eclampsia	Severe Preeclampsia Antepartum Severe Pre-Eclampsia Postpartum Severe Pre-Eclampsia Severe Pre-Eclampsia, With Delivery Severe Toxemia Severe Pre-Eclampsia, Antepartum Condition Or Complication Severe Pre-Eclampsia, Postpartum Condition Or Complication Severe Puerperal Pre-Eclampsia Severe Pre-Eclamptic Toxaemia Severe Pet - [Pre-Eclamptic Toxaemia]
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Legg-Calve-Perthes Disease	Perthes Disease LCPD Coxa Plana Legg-Perthes Disease Juvenile Osteochondrosis Of Hip And Pelvis Pseudocoxalgia Legg-Calvé-Perthes Disease Lcp Calve - Perthes' Disease Juvenile Osteochond-Hip/Pelvis Juvenile Osteochondrosis Of Hip And/Or Pelvis Legg-Calve-Perthes Symptom Osteochondrosis Of Legg-Calve-Perthes Perthe'S Disease Legg-Calve-Perthes Syndrome Osteochondritis Deformans Calve-Perthes Disease Aseptic Necrosis Of The Capital Femoral Epiphysis Osteochondrosis Of The Capital Femoral Epiphysis Legg-Calvé-Perthes Syndrome Avascular Necrosis Of The Capital Femoral Epiphysis
Ovarian Hyperstimulation Syndrome	OHSS Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous Secondary Meig'S Syndrome Ohss - [Ovarian Hyperstimulation Syndrome] Hyperstimulation Of Ovaries Nos Hyperstimulation Of Ovaries Associated With Induced Ovulation
Dysfibrinogenemia, Congenital	Dysfibrinogenemia Hypodysfibrinogenemia Familial Dysfibrinogenemia Familial Hypodysfibrinogenemia Hypodysfibrinogenemia, Congenital Dysfibrinogenemia, Familial Congenital Dysfibrinogenemia DYSFIBRIN
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Sagittal Sinus Thrombosis	Thrombosis Of Superior Longitudinal Sinus Thrombosis Of Superior Sagittal Sinus Thrombosis Superior Sagittal Sinus
Intracranial Hypertension	Raised Intracranial Pressure
Scott Syndrome	SCTS Bdplt7 Prothrombin Consumption Deficiency Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X Bleeding Disorder, Platelet-Type, 7 Prothrombin Conversion Defect, Familial Prothrombin Consumption Inhibitor, Familial Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X Familial Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Platelet-Type Bleeding Disorder 7 Platelet Factor X Receptor Deficiency Bleeding Disorder Platelet-Type 7 Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Familial
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Venous Insufficiency	Peripheral Venous Insufficiency
Prothrombin Deficiency, Congenital	Dysprothrombinemia Hypoprothrombinemia Congenital Factor Ii Deficiency Prothrombin Deficiency Factor Ii Deficiency Congenital Prothrombin Deficiency FA2D Hypoprothrombinemias Inherited Factor Ii Deficiency Hereditary Factor Ii Deficiency Disease
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Meningococcemia
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Thrombasthenia
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Factor X Deficiency	Stuart-Prower Factor Deficiency F10 Deficiency Congenital Stuart Factor Deficiency Factor X Deficiency, Congenital Congenital Factor X Deficiency Disease, Stuart-Prower Stuart Factor Deficiency, Congenital FA10D Factor 10 Deficiency Deficiency, Factor X Hereditary Factor X Deficiency Disease Deficiency Of Factor X Stuart Deficiency Disease Stuart Prower Deficiency Stuart-Prower Disease
Gastroschisis	Laparoschisis Congenital Fissure Of The Abdominal Cavity Abdominal Wall Defect Abdominal Hernia Hernia, Abdominal Omphalocele Abnormality Of The Abdominal Wall Congenital Omphalocele Coeloschisis Coelioschisis Celoschisis Congenital Para-Umbilical Hernia
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1	Cadasil Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Casil Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Familial Vascular Leukoencephalopathy CADASIL1 Cadasil 1 Hereditary Multi-Infarct Dementia Cadasil Syndrome Dementia, Hereditary Multiinfarct Type Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1 Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy Dementia, Hereditary Multi-Infarct Type Hereditary Dementia, Multi-Infarct Type Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1 Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant Dementia Hereditary Multiinfarct Type Dementia Hereditary Multi-Infarct Type Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0039	BIM-26226	Antagonist	98.73%	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112698	CA-5f		99.14%	Unkown
HY-108277	Ginsenoside F5	Inducer	99.90%	Unkown
HY-W093272	Thalidomide-5,6-F	Inducer	99.84%	Unkown
HY-132226	Desamino lenalidomide-5-F		97.72%	Unkown
HY-124421	5F-203	Inducer	98.04%	Unkown
HY-W010811	Fmoc-Phe(F5)-OH		99.08%	Unkown
HY-P5367	5-FAM-PMDM6		97.06%	Unkown
HY-R01575	hsa-miR-518f-5p mimic		92.38%	Unkown
HY-RI01575	hsa-miR-518f-5p inhibitor		99.28%	Unkown
HY-118847	Antifungal agent 86	Inhibitor	/	Unkown
HY-147698	ZLHQ-5f		/	Unkown
HY-185609	m7G(2'F)(5')ppp(5')(2'OMeA)pG triammonium		/	Unkown
HY-D1410	DMTr-4'-F-5-Me-U-CED phosphoramidite		/	Unkown
HY-D1779	Fura-5F pentapotassium		/	Unkown
HY-N8311	Goshonoside F5	Inhibitor	/	Unkown
HY-P11865	Ac-ATS010-KE	Inhibitor	/	Unkown
HY-P2579	Dafphedyn	Agonist	/	Unkown
HY-P4020	2F5 epitope		/	Unkown
HY-P4025	ELDKWA		/	Unkown
HY-R01575A	hsa-miR-518f-5p agomir		/	Unkown
HY-R01604	hsa-miR-520f-5p mimic		/	Unkown
HY-R01604A	hsa-miR-520f-5p agomir		/	Unkown
HY-R01684	hsa-miR-548f-5p mimic		/	Unkown
HY-R01684A	hsa-miR-548f-5p agomir		/	Unkown
HY-R03052	mmu-miR-344f-5p mimic		/	Unkown
HY-R03052A	mmu-miR-344f-5p agomir		/	Unkown
HY-R03177	mmu-miR-466f-5p mimic		/	Unkown
HY-R03177A	mmu-miR-466f-5p agomir		/	Unkown
HY-R03468	mmu-miR-669f-5p mimic		/	Unkown
HY-R03468A	mmu-miR-669f-5p agomir		/	Unkown
HY-RI01575A	hsa-miR-518f-5p antagomir		/	Unkown
HY-RI01604	hsa-miR-520f-5p inhibitor		/	Unkown
HY-RI01604A	hsa-miR-520f-5p antagomir		/	Unkown
HY-RI01684	hsa-miR-548f-5p inhibitor		/	Unkown
HY-RI01684A	hsa-miR-548f-5p antagomir		/	Unkown
HY-RI03052	mmu-miR-344f-5p inhibitor		/	Unkown
HY-RI03052A	mmu-miR-344f-5p antagomir		/	Unkown
HY-RI03177	mmu-miR-466f-5p inhibitor		/	Unkown
HY-RI03177A	mmu-miR-466f-5p antagomir		/	Unkown
HY-RI03468	mmu-miR-669f-5p inhibitor		/	Unkown
HY-RI03468A	mmu-miR-669f-5p antagomir		/	Unkown
HY-RS04114	E2F5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04644	F5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09816	OR4F5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W124385	5,5-Difluoro-1,3-dimethyl-5H-5lambda4,6lambda4-dipyrrolo[1,2-c:2',1'-f][1,3		/	Unkown
HY-W877994	Thalidomide-6-F-5-pip-CHO		95.0%	Unkown
HY-180495	5-MeO-NBpBrT		/	Unkown
HY-201022	5'-O-DMT-2'-F-5-MeO-U-3'-CE Phosphoramidite		/	Unkown
HY-201028	5'-C2-O-DMT-2'-F-5-MeO-U-3'-CE Phosphoramidite		/	Unkown
HY-R04617	mmu-let-7f-5p mimic		/	Unkown
HY-RS16905	F5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20723	E2f5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23347	F5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27235	E2f5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W453715	Thalidomide-4-F,5-Br		99.37%	Unkown
HY-W586320	Thalidomide-5-Br,6-F		/	Unkown
HY-W998241	Thalidomide-6-F-5-azetidine-COOH		/	Unkown
HY-W998242	Thalidomide-6-F-5-Pip-COOH		/	Unkown
HY-W998335	(S)-Deoxy-thalidomide-6-F-5-piperazine benzenesulfonate		/	Unkown
HY-W998346	Thalidomide-5-NH2-6-F		/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990255	Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5)	Inhibitor	95.00%	Unkown
HY-P990221	Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F5	VGNC	VGNC:28688
Macaca mulatta	F5	VGNC	VGNC:99921
Canis familiaris	F5	VGNC	VGNC:40551
Mus musculus	F5	MGD	MGI:88382
Felis catus	F5	VGNC	VGNC:62027
Rattus norvegicus	F5	RGD	RGD:1589758
Others	F5	NCBI