2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-6-F-5-pip-CHO

Thalidomide-6-F-5-pip-CHO is a synthetic E3 ligase ligand-conjugate that can be used for the synthesis of PROTACs, such as DN1679 (HY-181035).

For research use only. We do not sell to patients.

Thalidomide-6-F-5-pip-CHO

Thalidomide-6-F-5-pip-CHO Chemical Structure

CAS No. : 2505502-00-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Thalidomide-6-F-5-pip-CHO Related Antibodies

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Description

Thalidomide-6-F-5-pip-CHO is a synthetic E3 ligase ligand-conjugate that can be used for the synthesis of PROTACs, such as DN1679 (HY-181035)[1].

Molecular Weight

387.36

Formula

C19H18FN3O5
CAS No.
Appearance

Solid

SMILES

O=CC1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2F)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (64.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5816 mL 12.9079 mL 25.8158 mL
5 mM 0.5163 mL 2.5816 mL 5.1632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5816 mL 12.9079 mL 25.8158 mL 64.5394 mL
5 mM 0.5163 mL 2.5816 mL 5.1632 mL 12.9079 mL
10 mM 0.2582 mL 1.2908 mL 2.5816 mL 6.4539 mL
15 mM 0.1721 mL 0.8605 mL 1.7211 mL 4.3026 mL
20 mM 0.1291 mL 0.6454 mL 1.2908 mL 3.2270 mL
25 mM 0.1033 mL 0.5163 mL 1.0326 mL 2.5816 mL
30 mM 0.0861 mL 0.4303 mL 0.8605 mL 2.1513 mL
40 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6135 mL
50 mM 0.0516 mL 0.2582 mL 0.5163 mL 1.2908 mL
60 mM 0.0430 mL 0.2151 mL 0.4303 mL 1.0757 mL
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Thalidomide-6-F-5-pip-CHO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-6-F-5-pip-CHO2505502-00-9E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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