1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Topoisomerase
    Apoptosis
  3. ZLHQ-5f

ZLHQ-5f 

Cat. No.: HY-147698
Handling Instructions

ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile.

For research use only. We do not sell to patients.

ZLHQ-5f Chemical Structure

ZLHQ-5f Chemical Structure

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Description

ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile[1].

IC50 & Target

CDK2/CycA2

0.145 μM (IC50)

Top1

 

In Vitro

ZLHQ-5f shows antiproliferative activity with GI50 values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.53

Formula

C28H25N5O2

SMILES

N[[email protected]]1CCN(C1)C2=C3OC4=C(C3=NC5=CC=C(C=C52)C6=CC(NC(C7CC7)=O)=NC=C6)C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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ZLHQ-5f
Cat. No.:
HY-147698
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