2851977-85-8
2851977-85-8
Chemical Structure
ZLHQ-5f
- CAS No.: 2851977-85-8
- Formula:C28H25N5O2
- Molecular Weight:463.53
IUPAC Name: (S)-N-(4-(11-(3-aminopyrrolidin-1-yl)benzofuro[3,2-b]quinolin-2-yl)pyridin-2-yl)cyclopropanecarboxamide
InChIKey: HGUCVADITYSNHR-IBGZPJMESA-N
SMILES: N[C@H]1CCN(C1)C2=C3OC4=C(C3=NC5=CC=C(C=C52)C6=CC(NC(C7CC7)=O)=NC=C6)C=CC=C4
Biological Activity: ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile[1].
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ZLHQ-5f | ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile. | |||||||||||||||||||||
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References
Keywords
