2. Gene
  3. Ufd1 - ubiquitin recognition factor in ER-associated degradation 1 Gene

Ufd1 - ubiquitin recognition factor in ER-associated degradation 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ufd1l

Gene ID: 22230 | Gene type: protein coding

About Ufd1

Summary

Enables K48-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ERAD pathway; negative regulation of RIG-I signaling pathway; and negative regulation of type I interferon production. Located in cytoplasm. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in several structures, including brain; branchial arch; cardiovascular system; forelimb bud; and sensory organ. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Apr 2022]

Ufd1 Products(1)

mRNA Protein Name
NM_011672.4 NP_035802.3 ubiquitin recognition factor in ER-associated degradation protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
12847084 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10811609 MGI
Biological Process GO Annotation Evidence Reference Source
involved in ERAD pathway EXP
EXP: Inferred from Experiment
12847084 MGI
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 MGI
Cellular Component GO Annotation Evidence Reference Source
part of UFD1-NPL4 complex IDA
IDA: Inferred from direct assay
10811609 MGI
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 MGI
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
10811609 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18775783 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin recognition factor in ER-associated degradation protein 1

UB fusion protein 1

ubiquitin fusion degradation 1 like

ubiquitin fusion degradation protein 1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W111581 Copper(II) diethyldithiocarbamate Inducer 98.5% Unkown
HY-RS15414 UFD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ufd1 NCBI NCBI:7353