Vamp1 - vesicle-associated membrane protein 1 Gene

Also Known as lew; Syb1; Syb-1; VAMP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22317

Summary

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in cell surface. Is active in glutamatergic synapse and neuromuscular junction. Is expressed in brain; cerebellum molecular layer; and ventral tegmental area. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Vamp1 Products (2)

mRNA Protein Name
NM_001080557.1 NP_001074026.1 vesicle-associated membrane protein 1 isoform b
NM_009496.3 NP_033522.1 vesicle-associated membrane protein 1 isoform a

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IDA
IDA: Inferred from direct assay
21151919 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
IDA: Inferred from direct assay
21282288 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
21282288 MGI
involved in synaptic vesicle priming IDA
IDA: Inferred from direct assay
24944211 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
24944211 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21151919 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24944211 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24944211 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
21282288 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
21282288 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 1

  • synaptobrevin-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15593 VAMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp1 NCBI NCBI:6843