Wnt11 - wingless-type MMTV integration site family, member 11 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22411

Summary

Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in heart development and positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including Wnt signaling pathway; animal organ development; and regulation of cytokine production. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Apr 2022]

Wnt11 Products (4)

mRNA Protein Name
NM_001285792.1 NP_001272721.1 protein Wnt-11 isoform a precursor
NM_001285794.1 NP_001272723.1 protein Wnt-11 isoform b
NM_001285795.1 NP_001272724.1 protein Wnt-11 isoform c
NM_009519.2 NP_033545.1 protein Wnt-11 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
17767158 MGI
involved in atrial septum development IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
17767158 MGI
acts upstream of or within bone mineralization IGI
IGI: Inferred from genetic interaction
19213727 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19213727 MGI
acts upstream of or within cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within convergent extension involved in axis elongation IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within kidney development IDA
IDA: Inferred from direct assay
21281623 MGI
acts upstream of or within maintenance of epithelial cell apical/basal polarity IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within negative regulation of fibroblast growth factor production IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within negative regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17767158 MGI
acts upstream of or within notochord morphogenesis IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
19213727 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
17767158 MGI
acts upstream of or within paraxial mesoderm formation IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18191119 MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production IMP
IMP: Inferred from mutant phenotype
17767158 MGI
involved in primary heart field specification IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
18191119 MGI
involved in secondary heart field specification IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within somite development IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
18191119 MGI
involved in ventricular septum development IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
17767158 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
8700530 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
18155657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-11

  • wingless-related MMTV integration site 11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0899 Wilforine Inhibitor 99.47% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt11 NCBI NCBI:7481