Wnt11 - wingless-type MMTV integration site family, member 11 Gene

Mus musculus

Gene ID: 22411 | Gene type: protein coding

About Wnt11

Summary

Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in heart development and positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including Wnt signaling pathway; animal organ development; and regulation of cytokine production. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Apr 2022]

Wnt11 Products(4)

mRNA	Protein	Name
NM_001285792.1	NP_001272721.1	protein Wnt-11 isoform a precursor
NM_001285794.1	NP_001272723.1	protein Wnt-11 isoform b
NM_001285795.1	NP_001272724.1	protein Wnt-11 isoform c
NM_009519.2	NP_033545.1	protein Wnt-11 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18606138	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	17767158	MGI
involved in atrial septum development	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	17767158	MGI
acts upstream of or within bone mineralization	IGI IGI: Inferred from genetic interaction	19213727	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19213727	MGI
acts upstream of or within cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	25959411	MGI
acts upstream of or within convergent extension involved in axis elongation	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within kidney development	IDA IDA: Inferred from direct assay	21281623	MGI
acts upstream of or within maintenance of epithelial cell apical/basal polarity	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within negative regulation of fibroblast growth factor production	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within negative regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17767158	MGI
acts upstream of or within notochord morphogenesis	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	19213727	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17767158	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production	IMP IMP: Inferred from mutant phenotype	17767158	MGI
involved in primary heart field specification	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	18191119	MGI
involved in secondary heart field specification	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within somite development	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
involved in ventricular septum development	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17767158	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	8700530	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	18155657	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-11

wingless-related MMTV integration site 11

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0899	Wilforine	Inhibitor	99.47%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt11	NCBI	NCBI:7481

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