Safb - scaffold attachment factor B Gene

Also Known as HAP; HET; SAFB1; SAF-B1; E130307D12; 3110021E02Rik; 5330423C17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224903

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within hormone metabolic process; intracellular Estrogen receptor signaling pathway; and regulation of growth. Predicted to be located in midbody and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; olfactory epithelium; reproductive system; and retina layer. Orthologous to human SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Apr 2022]

Safb Products (2)

mRNA Protein Name
NM_001163300.1 NP_001156772.1 scaffold attachment factor B1 isoform 2
NM_001374619.1 NP_001361548.1 scaffold attachment factor B1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19403048 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19403048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17931718 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15798188 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
15798188 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19403048 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
15798188 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

scaffold attachment factor B1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181794 Z19024498 Activator / Unkown
HY-RS12413 SAFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12414 SAFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Safb NCBI NCBI:6294