Plaat3 - phospholipase A and acyltransferase 3 Gene

Also Known as AdPLA; HRSL3; MLP-3; Hrasls3; Hrev107; Pla2g16

Species: Mus musculus

Gene Type: protein coding

Gene ID: 225845

Summary

Enables Phospholipase A1 activity and Phospholipase A2 activity. Involved in several processes, including ether lipid metabolic process; lens fiber cell differentiation; and triglyceride metabolic process. Acts upstream of or within response to bacterium. Located in several cellular components, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Orthologous to human PLAAT3 (Phospholipase A and Acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]

Plaat3 Products (2)

mRNA	Protein	Name
NM_001362425.1	NP_001349354.1	phospholipase A and acyltransferase 3
NM_139269.2	NP_644675.2	phospholipase A and acyltransferase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables acyltransferase activity	IDA IDA: Inferred from direct assay	18614531	MGI
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	19047760	MGI
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	18614531	MGI
enables phospholipase activity	IDA IDA: Inferred from direct assay	33854238	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ether lipid metabolic process	IMP IMP: Inferred from mutant phenotype	22134920	MGI
involved in lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	33854238	MGI
involved in lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19136964	MGI
involved in membrane disassembly	IDA IDA: Inferred from direct assay	33854238	MGI
involved in organelle disassembly	IMP IMP: Inferred from mutant phenotype	33854238	MGI
involved in peroxisome organization	IMP IMP: Inferred from mutant phenotype	22134920	MGI
involved in phospholipid biosynthetic process	IDA IDA: Inferred from direct assay	18614531	MGI
involved in phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	37919452	MGI
involved in regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	19136964	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	19136964	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	33854238	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18614531	MGI
located in lysosome	IDA IDA: Inferred from direct assay	33854238	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	33854238	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	33854238	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18614531	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	22134920	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phospholipase A and acyltransferase 3	H-rev 107 protein homolog HRAS-like suppressor 3 LRAT-like protein 3 adipose-specific phospholipase A2 group XVI phospholipase A1/A2 group XVI phospholipase A2 phospholipase A2, group XVI

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10638	PLAAT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plaat3	NCBI	NCBI:11145