PLAAT3 - phospholipase A and acyltransferase 3 Gene

Also Known as AdPLA; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11145

About PLAAT3

Cytogenetic location: 11q12.3-q13.1 Genomic coordinates (GRCh38): 11:63,574,462-63,616,927 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 7 paralogues. Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues.

Summary

Enables N-acyltransferase activity; Phospholipase A1 activity; and Phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Apr 2022]

PLAAT3 Products (2)

mRNA Protein Name
NM_001128203.2 NP_001121675.1 phospholipase A and acyltransferase 3
NM_007069.3 NP_009000.2 phospholipase A and acyltransferase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables N-acyltransferase activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables lipid binding EXP
EXP: Inferred from Experiment
22605381 GOA
enables phospholipase A1 activity IDA
IDA: Inferred from direct assay
19047760 GOA
enables phospholipase A2 activity IDA
IDA: Inferred from direct assay
19047760 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
22825852 GOA
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
20100577 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT3 Protein Structure

LRAT

LRAT: Lecithin retinol acyltransferase (6 - 125)

  • 0
  • 100
  • 162 a.a.
Protein Preferred Names Protein Names

phospholipase A and acyltransferase 3

  • Ca-independent phospholipase A1/2

PLAAT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
PLAAT3 P53816 PPP2R1A Homo sapiens P30153
Confocal
17374643
Intra
PLAAT3 P53816 PPP2R1A Homo sapiens P30153
Anti Bait CoIP
17374643
Intra
PLAAT3 P53816 PPP2R1A Homo sapiens P30153
Pull Down
17374643
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
PLAAT3 P53816 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
PLAAT3 P53816 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PLAAT3 P53816 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PLAAT3 P53816 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLAAT3 Proteins

Cat. No. Product Name Accession Purity
HY-P71211 PLA2G16 Protein, Human (His) P53816 (D12-D132) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Poland Syndrome

  • Poland Anomaly

  • Poland Sequence

  • Poland Syndactyly

  • Poland'S Syndrome

  • Poland'S Anomaly

  • Poland'S Syndactyly

  • Acro-Pectoro-Renal Field Defect

  • Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys

  • Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand

  • Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Acute Flaccid Myelitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10638 PLAAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLAAT3 RGD RGD:2829
Mus musculus PLAAT3 MGD MGI:2179715
Macaca mulatta PLAAT3 VGNC VGNC:76055
Canis familiaris PLAAT3 VGNC VGNC:57387
Others PLAAT3 NCBI