Smc5 - structural maintenance of chromosomes 5 Gene

Also Known as SMC-5; mSMC5; Smc5l1; MLZ-453; mKIAA0594

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226026

Summary

Predicted to enable ATP binding activity and ATP hydrolysis activity. Acts upstream of or within several processes, including chromosome condensation; internal peptidyl-lysine acetylation; and protein localization to chromosome, centromeric region. Located in PML body; chromosome; and cytoplasm. Part of Smc5-Smc6 complex. Is expressed in ovary; secondary spermatocyte; and testis. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Apr 2022]

Smc5 Products (3)

mRNA Protein Name
NM_001252684.1 NP_001239613.1 structural maintenance of chromosomes protein 5 isoform 1
NM_001252685.1 NP_001239614.1 structural maintenance of chromosomes protein 5 isoform 3
NM_153808.2 NP_722503.1 structural maintenance of chromosomes protein 5 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome condensation IMP
IMP: Inferred from mutant phenotype
26919979 MGI
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
26919979 MGI
acts upstream of or within internal peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
26919979 MGI
acts upstream of or within mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
26919979 MGI
acts upstream of or within protein localization to chromosome, centromeric region IMP
IMP: Inferred from mutant phenotype
26919979 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
26919979 MGI
Cellular Component GO Annotation Evidence References Source
located in PML body IMP
IMP: Inferred from mutant phenotype
19793919 MGI
part of Smc5-Smc6 complex IDA
IDA: Inferred from direct assay
26919979 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
19793919 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
26919979 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20339383 MGI
located in sex chromosome IDA
IDA: Inferred from direct assay
11408570 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 5

  • SMC protein 5

  • SMC5 structural maintenance of chromosomes 5-like 1

  • protein expressed in male leptotene and zygotene spermatocytes 453

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13421 SMC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc5 NCBI NCBI:23137