Fbxo2 - F-box protein 2 Gene

Also Known as FBG1; FBX2; Fbs1; Fbs2; NFB42; Prpl4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 230904

Summary

Enables amyloid-beta binding activity and carbohydrate binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Acts upstream of or within glycoprotein catabolic process; regulation of protein ubiquitination; and ubiquitin-dependent ERAD pathway. Located in cytosol and dendritic spine. Part of SCF ubiquitin Ligase complex. Is expressed in brain; testis; and vestibulo-cochlear ganglion. Orthologous to human FBXO2 (F-box protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Fbxo2 Products (1)

mRNA	Protein	Name
NM_176848.1	NP_789818.1	F-box only protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	9173930	MGI
enables carbohydrate binding	IDA IDA: Inferred from direct assay	12939278	MGI
enables denatured protein binding	IDA IDA: Inferred from direct assay	15723043	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15723043	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ERAD pathway	IDA IDA: Inferred from direct assay	15723043	MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	12140560	MGI
acts upstream of or within glycoprotein catabolic process	IDA IDA: Inferred from direct assay	15723043	MGI
involved in glycoprotein catabolic process	IDA IDA: Inferred from direct assay	12140560	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	12140560	MGI
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	15809437	MGI
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	15809437	MGI
acts upstream of or within regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	15809437	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15723043	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12140560	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12140560	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	15809437	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15809437	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15809437	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
F-box only protein 2	prion protein ligand 4

Fbxo2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Fbxo2	Q80UW2	RNASE1	Bos taurus	P61823	X-Ray Diffraction	17389369
Cross	Fbxo2	Q80UW2	RNASE1	Bos taurus	P61823	GMS	17389369

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04797	FBXO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fbxo2	NCBI	NCBI:26232