Alkbh2 - alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Gene

Also Known as Abh2; mABH2; 9530023G02

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231642

Summary

Enables 2-oxoglutarate-dependent dioxygenase activity and cytosine C-5 DNA demethylase activity. Predicted to be involved in DNA dealkylation involved in DNA repair and oxidative DNA demethylation. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleoplasm. Orthologous to human ALKBH2 (alkB homolog 2, alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alkbh2 Products (3)

mRNA Protein Name
NM_001359940.1 NP_001346869.1 DNA oxidative demethylase ALKBH2
NM_001359941.1 NP_001346870.1 DNA oxidative demethylase ALKBH2
NM_175016.3 NP_778181.2 DNA oxidative demethylase ALKBH2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
16174769 MGI
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
16174769 MGI
enables broad specificity oxidative DNA demethylase activity IMP
IMP: Inferred from mutant phenotype
18519673 MGI
enables cytosine C-5 DNA demethylase activity IDA
IDA: Inferred from direct assay
16174769 MGI
NOT enables endonuclease activity IDA
IDA: Inferred from direct assay
16174769 MGI
NOT enables exonuclease activity IDA
IDA: Inferred from direct assay
16174769 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA alkylation repair IMP
IMP: Inferred from mutant phenotype
18519673 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA oxidative demethylase ALKBH2

  • alkB, alkylation repair homolog 2

  • alkylated DNA repair protein alkB homolog 2

  • alpha-ketoglutarate-dependent dioxygenase alkB homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168708 AH2-14c 98.01% Unkown
HY-RS00604 ALKBH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alkbh2 NCBI NCBI:121642