2. Gene
  3. Gcn1 - GCN1 activator of EIF2AK4 Gene

Gcn1 - GCN1 activator of EIF2AK4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GCN1L; Gcn1l1; mKIAA0219; 4932409G22; G431004K08Rik

Gene ID: 231659 | Gene type: protein coding

About Gcn1

Summary

Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ribosome binding activity. Involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Part of polysome. Is expressed in several structures, including gut; heart; hemolymphoid system gland; liver; and lung. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Apr 2022]

Gcn1 Products(1)

mRNA Protein Name
NM_172719.2 NP_766307.2 eIF-2-alpha kinase activator GCN1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15937339 MGI
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
24333428 MGI
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
32324833 MGI
Biological Process GO Annotation Evidence Reference Source
involved in GCN2-mediated signaling IDA
IDA: Inferred from direct assay
24333428 MGI
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
32324833 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23447528 MGI
is active in cytoplasm IMP
IMP: Inferred from mutant phenotype
32324833 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eIF-2-alpha kinase activator GCN1

GCN1 eIF-2-alpha kinase activator homolog

GCN1 general control of amino-acid synthesis 1-like 1

GCN1-like protein 1

general control of amino-acid synthesis 1-like protein 1

translational activator GCN1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W319647 GCN2 activator-1 Inhibitor 99.69% Unkown
HY-177569 NVS1.1 Degrader / Unkown
HY-177757 NVS2.1 Degrader / Unkown
HY-RS05337 GCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcn1 NCBI NCBI:10985