2. Gene
  3. Syne4 - spectrin repeat containing, nuclear envelope family member 4 Gene

Syne4 - spectrin repeat containing, nuclear envelope family member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KASH4; Nesp4; 0610012K07Rik

Gene ID: 233066 | Gene type: protein coding

About Syne4

Summary

Involved in establishment of epithelial cell apical/basal polarity. Is integral component of nuclear outer membrane. Is expressed in ganglia; metanephros; olfactory epithelium; pancreas; and pituitary gland. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 76. Orthologous to human SYNE4 (spectrin repeat containing nuclear envelope family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Syne4 Products(2)

mRNA Protein Name
NM_001290565.1 NP_001277494.1 nesprin-4 isoform 2
NM_153577.2 NP_705805.1 nesprin-4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19164528 MGI
Biological Process GO Annotation Evidence Reference Source
involved in establishment of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
19164528 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
19164528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nesprin-4

KASH domain-containing protein 4

nuclear envelope spectrin repeat protein 4

Syne4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Syne4 Q8CII8 KIF5B Homo sapiens P33176
Anti Tag CoIP
19164528
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14088 SYNE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syne4 NCBI NCBI:163183