CTDNEP1 - CTD nuclear envelope phosphatase 1 Gene

Also Known as NET56; DULLARD; HSA011916

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23399

About CTDNEP1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,243,591-7,251,978 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 230 orthologues and 5 paralogues. Ubiquitous expression in spleen (RPKM 30.6), appendix (RPKM 29.9) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Part of Nem1-Spo7 Phosphatase complex. [provided by Alliance of Genome Resources, Apr 2022]

CTDNEP1 Products (2)

mRNA Protein Name
NM_001143775.2 NP_001137247.1 CTD nuclear envelope phosphatase 1
NM_015343.5 NP_056158.2 CTD nuclear envelope phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22134922 GOA
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
17420445 GOA
Biological Process GO Annotation Evidence References Source
involved in nuclear envelope organization IDA
IDA: Inferred from direct assay
17420445 GOA
involved in positive regulation of triglyceride biosynthetic process IGI
IGI: Inferred from genetic interaction
22134922 GOA
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
17420445 GOA
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
22134922 GOA
Cellular Component GO Annotation Evidence References Source
part of Nem1-Spo7 phosphatase complex IDA
IDA: Inferred from direct assay
22134922 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22134922 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
17420445 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
17420445 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
22134922 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDNEP1 Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (62 - 231)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

CTD nuclear envelope phosphatase 1

  • C-terminal domain nuclear envelope phosphatase 1

CTDNEP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTDNEP1 O95476 CNEP1R1 Homo sapiens Q8N9A8
IF
22134922
Intra
CTDNEP1 O95476 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
CTDNEP1 O95476 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
CTDNEP1 O95476 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03289 CTDNEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTDNEP1 VGNC VGNC:71440
Bos taurus CTDNEP1 VGNC VGNC:27789
Canis familiaris CTDNEP1 VGNC VGNC:39691
Felis catus CTDNEP1 VGNC VGNC:61245
Rattus norvegicus CTDNEP1 RGD RGD:1310172
Mus musculus CTDNEP1 MGD MGI:1914431
Others CTDNEP1 NCBI